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Database: UniProt
Entry: T1G8W2_HELRO
LinkDB: T1G8W2_HELRO
Original site: T1G8W2_HELRO 
ID   T1G8W2_HELRO            Unreviewed;       643 AA.
AC   T1G8W2;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   08-MAY-2019, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO12860.1, ECO:0000313|EnsemblMetazoa:HelroP93524};
GN   Name=20217509 {ECO:0000313|EnsemblMetazoa:HelroP93524};
GN   ORFNames=HELRODRAFT_93524 {ECO:0000313|EMBL:ESO12860.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Lophotrochozoa; Annelida; Clitellata; Hirudinea;
OC   Hirudinida; Glossiphoniiformes; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP93524, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|EnsemblMetazoa:HelroP93524, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Simakov O., Marletaz F.,
RA   Cho S.-J., Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T.,
RA   Lv J., Arendt D., Savage R., Osoegawa K., de Jong P., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESO12860.1, ECO:0000313|EnsemblMetazoa:HelroP93524, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP93524}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC       {ECO:0000256|RuleBase:RU003968}.
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DR   EMBL; AMQM01000252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB095811; ESO12860.1; -; Genomic_DNA.
DR   RefSeq; XP_009009580.1; XM_009011332.1.
DR   EnsemblMetazoa; HelroT93524; HelroP93524; HelroG93524.
DR   GeneID; 20217509; -.
DR   KEGG; hro:HELRODRAFT_93524; -.
DR   CTD; 20217509; -.
DR   OMA; FQNGVYP; -.
DR   OrthoDB; 798314at2759; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015101};
KW   FAD {ECO:0000256|PIRSR:PIRSR000137-2, ECO:0000256|RuleBase:RU003968};
KW   Flavoprotein {ECO:0000256|RuleBase:RU003968};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM      6     30       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      123    146       GMC_OxRdtase_N. {ECO:0000259|PROSITE:
FT                                PS00623}.
FT   BINDING     129    129       FAD. {ECO:0000256|PIRSR:PIRSR000137-2}.
SQ   SEQUENCE   643 AA;  71674 MW;  21EB47186D03D7F2 CRC64;
     MSIGKYIPAI IVVGIGLTFY RLLGLGDYFV ELIKAKELQK EYDYIIVGGG TAGAVLAARL
     ADNKDFNILL VEAGSNPSSN PLVDIPLMAD SIRTPQLDWH HKTVPQKFAC KGHVDQSAII
     HSGKGLGGTS NINYMQYLRG SRYDYDGWAL NGAAGWAYKD VLPYFIKSED QQNGEFVRTV
     FHGFGGRLAV KDVGPTTMNQ IMGLCFKEIS LKKRDLNGKN QFGWGPTQAT IRNGVRWSTF
     KAYLKRYMNA PNLHVVTDTF AEKILFEGKR ADSIVLKHEK KTEVVKAKKE IILTAGTVGT
     TKLLLLSGVG PKTHLQKLKI PVVADLPVGE NLQDQVVGDG IEYYTPYPGV SITINMADSL
     LSSWAYSLFG TEVTTSLAGM KSSPRFREAT AYIRLRHQPP NIKYPLLALH IAANPQAYEA
     TSKLHTAHDL FQTWAEIHGK PLSREGFTIF PVLLHPRSRG TIRLNTTNPE DPPLIDPNYL
     SEEIDIKILT EGFQFARRLL HTQVMKDWEF KLTNRLLPEC QKYGNYTNAY VECHLRHITI
     PGGNLVGTCK MGALNDPRAV VDPILRVRGL KGLRVADASI IPTSMSADTY ATQVMIAEKA
     ADFILEKDTV RSIKEYFKHL IESRHKKIMD DEEAEEAHTA KKS
//
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