ID T1G925_HELRO Unreviewed; 446 AA.
AC T1G925;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=CS domain-containing protein {ECO:0000259|PROSITE:PS51203};
GN Name=20217572 {ECO:0000313|EnsemblMetazoa:HelroP94727};
GN ORFNames=HELRODRAFT_94727 {ECO:0000313|EMBL:ESO02670.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP94727, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO02670.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP94727}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01000987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096742; ESO02670.1; -; Genomic_DNA.
DR RefSeq; XP_009020078.1; XM_009021830.1.
DR AlphaFoldDB; T1G925; -.
DR STRING; 6412.T1G925; -.
DR EnsemblMetazoa; HelroT94727; HelroP94727; HelroG94727.
DR GeneID; 20217572; -.
DR KEGG; hro:HELRODRAFT_94727; -.
DR CTD; 20217572; -.
DR eggNOG; KOG1124; Eukaryota.
DR HOGENOM; CLU_029084_0_0_1; -.
DR InParanoid; T1G925; -.
DR OMA; PPYLFEV; -.
DR OrthoDB; 167568at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003341; P:cilium movement; IBA:GO_Central.
DR GO; GO:0036159; P:inner dynein arm assembly; IBA:GO_Central.
DR GO; GO:0036158; P:outer dynein arm assembly; IBA:GO_Central.
DR Gene3D; 2.60.40.790; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46492; DYNEIN ASSEMBLY FACTOR 4, AXONEMAL; 1.
DR PANTHER; PTHR46492:SF1; DYNEIN AXONEMAL ASSEMBLY FACTOR 4; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF13414; TPR_11; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51203; CS; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 3..87
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT REPEAT 388..421
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 158..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 52601 MW; 3908D23F56BAE8C1 CRC64;
MPIIVKDYEW QENNEFLFIS VPLKSVNSKK VSLFTTNSYL KVHFSPFLFE CFLNGRINNE
ESKVEIGDGL VKFKLVKETQ AVWGSLEDPN SESEENRRIL REKALEEHRM AEENKLKTKE
ETIRSIKSFN VKQQMKLEQE NRAWIDHERT KEKIKFEEEM NEWKQQQQQQ SQQQLQQHHQ
QQPQQHHQQQ QHHQQQQHHQ QQQHHQQQQQ QIQHLRDDSI NNNNNNYNNN NIKNNKNINK
NNNNSNNKNI FDDVTPIRQT KTISISFTPR VFPTPTRESM APEEEEWLRK QAEAKRVINF
DDNNLKEEEK NPIWLRDKGN KFFQDGDYQA AINAYTHAIR LDCKLPSLYS NRAACHLKMG
NSFKCLEDSS KALEMLTPPV EQNRLSRIQA HIRRGTAFVT LKLFVEGLRD YEAALKLEPG
NDDLRKDAES IRRTIQSSSS SPPPAS
//
