ID T1G965_HELRO Unreviewed; 998 AA.
AC T1G965;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESN96607.1, ECO:0000313|EnsemblMetazoa:HelroP95514};
GN Name=20217612 {ECO:0000313|EnsemblMetazoa:HelroP95514};
GN ORFNames=HELRODRAFT_95514 {ECO:0000313|EMBL:ESN96607.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP95514, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN96607.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP95514}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR EMBL; AMQM01001431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097495; ESN96607.1; -; Genomic_DNA.
DR RefSeq; XP_009025270.1; XM_009027022.1.
DR AlphaFoldDB; T1G965; -.
DR STRING; 6412.T1G965; -.
DR EnsemblMetazoa; HelroT95514; HelroP95514; HelroG95514.
DR GeneID; 20217612; -.
DR KEGG; hro:HELRODRAFT_95514; -.
DR CTD; 20217612; -.
DR eggNOG; KOG0708; Eukaryota.
DR HOGENOM; CLU_001715_4_2_1; -.
DR InParanoid; T1G965; -.
DR OMA; WIASSDF; -.
DR OrthoDB; 2879721at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0043113; P:receptor clustering; IBA:GO_Central.
DR GO; GO:0097120; P:receptor localization to synapse; IBA:GO_Central.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd11861; SH3_DLG-like; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR015143; L27_1.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF51; DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF09058; L27_1; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 49..109
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 255..342
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 360..447
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 539..620
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 651..730
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 807..982
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 998 AA; 111500 MW; 0EDD4A3C18C2005D CRC64;
MSMPVKQSEG LGHTDHMIKN DIDNSNNNNN INDNDDDDSL KNLSSKTMSR SDAHRALELL
EEYYGRLIRP QDQNLRLAIE RVIRIFKSRL FQALLDIQEF YEVTLLDDEK SVEQKTDETL
LVASRWEENP PIASNRPLSN CHSDNSNVSF CREQLKANMT TAATSSSSNR QLQTWTLSLY
YQFVFDVILF FCFCVNALSK SLHQLSQQQQ QFQQLHYQQN NNTHQQQQQI PQQQQYQRQH
QPPHPITLDD WEYETINLDR GGTGLGFSIS GGTDNPHVGD DPGIYITKII ENRAASIDGR
LKINDMIVSV NGISTIDVTH AEAVAALKKA GNSVSLVVRR KKLMSSSSSS AAAPDDNVIL
LELVKRSKGL GFSIAGGVGN EHIPGDVGIY VTKVIDGGAA QVDGRLQVGD RLLAVNEVSL
DNVTHEEAVA ALKATREYVR LLIRKRPSYD DGSQPLTPLM GNSPRVMSSM PHLPMNHVTS
PHPHSLQQQP QQQQSLINNN STMSRFGNVN SSYSSINYNL GRTFSRGDDE HDVGREPRKV
VMKKGPNGLG FNIVGGEDGE GIFVSFILPG GSADLSGGLY RGDQLLSVNG IDITGATHEQ
AAVTLKSAGD VVEVIVIYKP EEYSRFEAKI HELREQMMSC GNTGSLRTTQ KKMLFVRALF
DYDPSKDSGL PGRGLIFKFG DILHVTNASD DEWWQAKKLT GYPGDSEDSG GIGGVGLGII
PSKKRVERKE RSRMKNVKFI GKSVSFLFLF LATLPADKNK KKIFGKKLSF TKVKDRSGSE
DALSADDLSD EPIASYEPVV QHEMKFPRPV IILGPLKDRL NDDLILEFPD KFSSCIPHTT
RPRREYEVDG RDYYFVESRD QMEKDIQNHM FIEAGQYNDN LYGTSIKSVR DVAESGKHCI
LDVSGNAIKR LQVAGLFPIA LFIKPKSYET VMEWNKRITE DQARKTFEQT LKIEHEFGEL
FTAIVTGDTG DEVYQNVKEV IAEQSGPIAW IPSQDIYL
//
