ID T1G986_HELRO Unreviewed; 971 AA.
AC T1G986;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=F-box domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20217633 {ECO:0000313|EnsemblMetazoa:HelroP95885};
GN ORFNames=HELRODRAFT_95885 {ECO:0000313|EMBL:ESN92575.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP95885, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN92575.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP95885}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01001742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097639; ESN92575.1; -; Genomic_DNA.
DR RefSeq; XP_009028908.1; XM_009030660.1.
DR AlphaFoldDB; T1G986; -.
DR STRING; 6412.T1G986; -.
DR EnsemblMetazoa; HelroT95885; HelroP95885; HelroG95885.
DR GeneID; 20217633; -.
DR KEGG; hro:HELRODRAFT_95885; -.
DR CTD; 20217633; -.
DR eggNOG; KOG1777; Eukaryota.
DR HOGENOM; CLU_005078_1_0_1; -.
DR InParanoid; T1G986; -.
DR OMA; KESFHQL; -.
DR OrthoDB; 5491826at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd19676; UBR-box_UBR6_FBXO11; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 3.
DR InterPro; IPR039448; Beta_helix.
DR InterPro; IPR006633; Carb-bd_sugar_hydrolysis-dom.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR047504; FBXO11_UBR-box.
DR InterPro; IPR022441; Para_beta_helix_rpt-2.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR003126; Znf_UBR.
DR NCBIfam; TIGR03804; para_beta_helix; 3.
DR PANTHER; PTHR22990; F-BOX ONLY PROTEIN; 1.
DR PANTHER; PTHR22990:SF20; F-BOX ONLY PROTEIN 11; 1.
DR Pfam; PF13229; Beta_helix; 2.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00722; CASH; 3.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00710; PbH1; 19.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 3.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 150..196
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT DOMAIN 877..948
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT ZN_FING 877..948
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 971 AA; 107783 MW; 207168E8571A3D64 CRC64;
MSSTPLHSTT KLRIQKNNSR RGGASSSGSS GNCNSNGVCG TSSSWGSSRR SSPMAARDIP
NSDSIADSQS VMGPDRMQRL SLPEHEQQCG PSRNRHRYDL RRKASSFNSS IDNATTVDNC
SFYNSPPKRL KCSRSSFCLS ASNMETVGGY YMQNELPDEV LLKIFSYLLE FDLSNVATVC
KRFNAVANDS ELWKKLYQNV FEYDLPLTTS ALEFGIFKFI NPSTINNNNN NNNFNNNNNN
YNNNNLWKDS FKCFYNSWHV RVGYKQEFEE NPQRYVGRKI KYFDSISEAY DHTLAVNQPQ
QQVHHQDNNN NNNDNSSDNN DNNSNNNKRP TIIFIHPGTY SKRLSITSNV ILIGAGPGNV
ADHVIIERQS ESAVLFSEGA KQAYLGYVTI KFSPSAPSSV PHHKHYSLEV TDNSSPIVDH
CTVKSFSVVG AAVCVSGSGA DPHIKHCNIS DCENVGLFIT DHAQGTYDYN EICRNALAGV
WVKNHANPIM RNNHIHHGRD VGIFTFDNGL GYFEGNEIHD NRIAGFEVKA GANPTVVKCH
IHHGQTGGIY VHENGRGQFM ENKIHSNNFA GIWVTSNSDP TIRRNEIFNG HQGGVYIFGE
GRGLIEYNDI HGNALAGIQI RTGSNPIVRH NKIHHGQHGG IYVHEKGQGL IEENEVYSNT
LAGVWITTNS QPILRKNRIH SGKQVGVYFY DNGHGTLEDN DIFNHLYSGV QIRTGSCPVI
KRNKIWGGQN GGILVYNGGL GVIENNEIFD NAMAGVWIKT DSNPTLRHNK IHDGRDGGVC
IFNGGKGILE SNEIFRNTQA GVLISNQSHP TLINNRIYDG MAAGIEITNN ATATLEGNKI
FNNKFGGLCL ASGVHPFTKD NVIYDNLNMV EKVVSSGQCL YKISSYTSFP MHDFYRCRTC
NTTDRNAICV NCIKTCHAGH VVEFIRHDRF FCDCGAGTLN NQCHLQGEPT QDTDTLYDSA
APMESHTLMV N
//
