ID T1G9I2_HELRO Unreviewed; 885 AA.
AC T1G9I2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=Alpha-actinin, sarcomeric {ECO:0008006|Google:ProtNLM};
GN Name=20217729 {ECO:0000313|EnsemblMetazoa:HelroP97639};
GN ORFNames=HELRODRAFT_97639 {ECO:0000313|EMBL:ESO09557.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP97639, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO09557.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP97639}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
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DR EMBL; AMQM01002988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095959; ESO09557.1; -; Genomic_DNA.
DR RefSeq; XP_009012650.1; XM_009014402.1.
DR AlphaFoldDB; T1G9I2; -.
DR STRING; 6412.T1G9I2; -.
DR EnsemblMetazoa; HelroT97639; HelroP97639; HelroG97639.
DR GeneID; 20217729; -.
DR KEGG; hro:HELRODRAFT_97639; -.
DR CTD; 20217729; -.
DR eggNOG; KOG0035; Eukaryota.
DR HOGENOM; CLU_005217_1_1_1; -.
DR InParanoid; T1G9I2; -.
DR OrthoDB; 2872403at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0030054; C:cell junction; IBA:GO_Central.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0055001; P:muscle cell development; IBA:GO_Central.
DR CDD; cd21214; CH_ACTN_rpt1; 1.
DR CDD; cd21216; CH_ACTN_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 3.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF442; ALPHA-ACTININ, SARCOMERIC-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 19..123
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 132..238
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 733..768
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 780..815
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 253..280
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 885 AA; 103574 MW; A236FD6F1F0D4DD4 CRC64;
MEQEDEWERE GLLDPAWEKQ QKKTFTAWCN SHLRKVGTQI EVIEEDFRDG LKLMLLLEVI
SGEQLPKPDR GKMRFHKIAN VNKALDFIES KGVKLVSIGA EEIVDGNLKM TLGMIWTIIL
RFAIQDISVE DFTAKEGLLL WCQRKTQPYR NVNVQNFHLS FKDGLAFCAL IHRHRPDLLD
YSKLSKENAR TNLTTAFDLA EKHLDIPRML DVDDMVNSVK PDERSVMAYV SSYYHAFSGA
QQAETAANRI CKVLKINQEN ERLMEEYEKL ASDLLEWIAR TKPWLENRSQ IQSIDATQKK
FEEFREYRSH QKPPRLDEKS MLETMYNSLQ TRLRLSNRPA YLPSEGKLIQ NIAVAWRELE
ESEKGFEDWL LSQLQRLERI AHLEKKFKQK YDKHVSWANG KEEMLTSDEY KKCRLDEVKA
LRKKHEAFES DLAAHQDRIE HINGIAQELN ALGYCNLKST NQKTQQLCEQ WGVLGELSIA
YKAKLEESEN VLERIDQLQL EYAKRAAHLN SWMDSTREDL EDIFNVHSIE EIEALLNSQK
KFKETLPDAE KELKETISLT EEVDRICEKY KLQINMENPF TSTQPKELRY KWQEFQKLVP
ARDQILQAEM TRQQRNDHLR MQFAQQANTL GPWIEQKLKF ISDLGVKRGT LEDHQQSLIK
LEQEVSANKP QIEQLEKCNQ EVQEARIFKN EHARYTMETI RVNWDQLVTS VSRNINELQN
QILMRDSRGI SHELIDECRK SFNHFDRSKN QYLEPKEFKA CLVSLGRSIR DDKQACHHFF
GDADFQKILQ KVDPNHNGYV TFDAFLDFMT MENTDSDSPD QIIESFKILS GNQPYITPKA
LRSEMPPEQA EYCIRRMTQY KGPDAPPDAL DYTSFSMGLY GESDL
//
