ID T1G9Q9_HELRO Unreviewed; 967 AA.
AC T1G9Q9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Exportin-2 {ECO:0000256|ARBA:ARBA00018945};
DE AltName: Full=Importin-alpha re-exporter {ECO:0000256|ARBA:ARBA00030693};
GN Name=20217805 {ECO:0000313|EnsemblMetazoa:HelroP99097};
GN ORFNames=HELRODRAFT_99097 {ECO:0000313|EMBL:ESO05215.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP99097, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO05215.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP99097}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the XPO2/CSE1 family.
CC {ECO:0000256|ARBA:ARBA00008669}.
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DR EMBL; AMQM01003892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096365; ESO05215.1; -; Genomic_DNA.
DR RefSeq; XP_009016530.1; XM_009018282.1.
DR AlphaFoldDB; T1G9Q9; -.
DR STRING; 6412.T1G9Q9; -.
DR EnsemblMetazoa; HelroT99097; HelroP99097; HelroG99097.
DR GeneID; 20217805; -.
DR KEGG; hro:HELRODRAFT_99097; -.
DR CTD; 20217805; -.
DR eggNOG; KOG1992; Eukaryota.
DR HOGENOM; CLU_009614_0_0_1; -.
DR InParanoid; T1G9Q9; -.
DR OMA; AENEFLM; -.
DR OrthoDB; 178772at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR005043; XPO2_C.
DR InterPro; IPR013713; XPO2_central.
DR PANTHER; PTHR10997:SF8; EXPORTIN-2; 1.
DR PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR Pfam; PF03378; CAS_CSE1; 1.
DR Pfam; PF08506; Cse1; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 29..103
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 967 AA; 109867 MW; 0AD1D525B2F8F310 CRC64;
MDITENNLQQ LGAYLQKTLS IDPAERRAAE KFLESIESNQ NYPILLLSLV DKTELPIHMR
ISGSVIFKNY IKRNWSIRDD GSDRIHANDR LVVKQNIIRL MLKAPEQIQK QLSDAISRIG
KEDFPDKWPN LMDEMIEKFS TSSDFHVING VLYTAHSIFK RYRHEFQSNK LWAEIKFVLD
KFALPFTQLT NKMMELAQMH ASSPDNLRLI YSSIILICKI FYSLNFQDLP EFFEDNMQTW
MNHFHVLLNA DCKLLETDDK DEPGVMEQVK TQVCDNLAMY AQKYDEEFGT YLPLFVTDVW
HLLINTGVSV KYDLLVSNAI QFLASVADRP GYKSLFEDPN TLASICEKII VPNMVFREAD
EEAFEDNAEE YIRRDIEGSD VDTRRRAACD LVRALSKSFE DTVIKNFSIY IQNMLQAYRE
NPQKNWKSKD AAIFLVTSLA AKAQTQKHGI TQTSSLVNVT EFFTNHIAPD LNSNANENPV
IKADAIKYIM VFRNQLSRDI LVSCLAPLVS LLLSGSHVVH SYSACCLDKM LSMKPAIITR
AELAPHGDLL LQNLFTAMNV VGSQENEYIM RGIMKSLHIL QDAFVPHVST IMGQLLSKLD
AVSKNPSKPH FNHCLFESLC IVISVVCRLN PGPEVINSFE SPLFPLFQNI LQQDVQEFVP
YIFQVLSLML EMHKNSIPVP YMSLFPILMQ PLLWERSGNV PALVRLLQAY IVIGCHNNQI
PADKLPGLLG IFQKLLASRS NDHFGMQLLN TMLVHVPHND MEKYIHQVFL LLFQKLTSSK
TTKYVKCVLV FFSLFIVKFS AAVFIEMVDK IQAKMFTMVL EKLYIAETAK ITNALDRKLC
AVAMTNILCE PTFLKDDSHP WLPLLKSLLE TLESAVAATS FAVEESPSIT ESAELEGFQA
AYSQLLYSGK QEVDYCIDVS DPKIYLAKKL HVLCHSTQKV KATLQGLPPQ AQNYLSAYFT
AAGVSIA
//
