ID   T1G9S2_HELRO            Unreviewed;       571 AA.
AC   T1G9S2;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=HD/PDEase domain-containing protein {ECO:0000259|SMART:SM00471};
GN   Name=20217818 {ECO:0000313|EnsemblMetazoa:HelroP99321};
GN   ORFNames=HELRODRAFT_99321 {ECO:0000313|EMBL:ESO04986.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP99321, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA   Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA   Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA   Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA   Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESO04986.1, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP99321}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC         deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC         ChEBI:CHEBI:18274, ChEBI:CHEBI:61560;
CC         Evidence={ECO:0000256|ARBA:ARBA00001432};
CC   -!- SIMILARITY: Belongs to the SAMHD1 family.
CC       {ECO:0000256|ARBA:ARBA00005776}.
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DR   EMBL; AMQM01004015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB096411; ESO04986.1; -; Genomic_DNA.
DR   RefSeq; XP_009016919.1; XM_009018671.1.
DR   AlphaFoldDB; T1G9S2; -.
DR   EnsemblMetazoa; HelroT99321; HelroP99321; HelroG99321.
DR   GeneID; 20217818; -.
DR   KEGG; hro:HELRODRAFT_99321; -.
DR   CTD; 20217818; -.
DR   eggNOG; KOG2681; Eukaryota.
DR   HOGENOM; CLU_026821_1_2_1; -.
DR   InParanoid; T1G9S2; -.
DR   OMA; ITHIGYR; -.
DR   OrthoDB; 123327at2759; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008832; F:dGTPase activity; IBA:GO_Central.
DR   GO; GO:0006203; P:dGTP catabolic process; IBA:GO_Central.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.70.2760; -; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR   PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT   DOMAIN          111..267
FT                   /note="HD/PDEase"
FT                   /evidence="ECO:0000259|SMART:SM00471"
SQ   SEQUENCE   571 AA;  65512 MW;  D83E7D84BFEF79F2 CRC64;
     MEKKRPASSL EAATAASTSA AVAASAAVAA STSAAADETE KVNNDFQSQN AGKMICYRET
     LLEKEGTIIN DPIHGHIEIS PLCMAIVNTP QFQRLRYIKQ VGSSSLVYPG AVHTRFEHSI
     GVCHLAETLC RTLQQKQPEL NITESDVSCV AIAGLCHDLG HGPFSHLYDQ LFVPIFRRFV
     KLPAWKHEKG SVDMLDYLLK VNNLKHLFSD DDLIFIKEQI LPPPNKDDYK GRGQDKLFLY
     EIVANKRNGI DVDKWDYFLR DSYYLGLKVS FDPGRLLKFV RVINVDGEKQ ICARAKEVDN
     LYEMYHCRIS LYKQAYLHKT TMIIDYMICE ALRLADDHLC FPGTNGKLYK MSECMNDMEA
     FWKMTDDIIL RILHTRKPEL SRSREWIRRV FSRKLPKIVG LVKESDNSRL KWSADWVHEQ
     LVIESVLLRM GLTTDDFIVI KRSFDYGMKE KNPLENCMFY SKHDPDVAYQ VRKNQVSSFL
     PEKFHEVQYL VYCNEDEKKS VANEVYVAVC LKHNLLISKG AEQNGLMMTP IRKDYFQPSD
     EPALKKRRES LHRNLVNEFL ASKGVDITGN L
//