ID T1G9S9_HELRO Unreviewed; 665 AA.
AC T1G9S9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=U-box domain-containing protein {ECO:0000259|PROSITE:PS51698};
GN Name=20217825 {ECO:0000313|EnsemblMetazoa:HelroP99472};
GN ORFNames=HELRODRAFT_99472 {ECO:0000313|EMBL:ESO04573.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP99472, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO04573.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP99472}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ubiquitin conjugation factor E4 family.
CC {ECO:0000256|ARBA:ARBA00007434}.
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DR EMBL; AMQM01004120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096457; ESO04573.1; -; Genomic_DNA.
DR RefSeq; XP_009017152.1; XM_009018904.1.
DR AlphaFoldDB; T1G9S9; -.
DR STRING; 6412.T1G9S9; -.
DR EnsemblMetazoa; HelroT99472; HelroP99472; HelroG99472.
DR GeneID; 20217825; -.
DR KEGG; hro:HELRODRAFT_99472; -.
DR CTD; 20217825; -.
DR eggNOG; KOG2042; Eukaryota.
DR HOGENOM; CLU_003224_2_1_1; -.
DR InParanoid; T1G9S9; -.
DR OMA; AMDTEAM; -.
DR OrthoDB; 1554at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0034450; F:ubiquitin-ubiquitin ligase activity; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR CDD; cd16658; RING-Ubox_UBE4B; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR019474; Ub_conjug_fac_E4_core.
DR InterPro; IPR045132; UBE4.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13931:SF2; UBIQUITIN CONJUGATION FACTOR E4 B; 1.
DR PANTHER; PTHR13931; UBIQUITINATION FACTOR E4; 1.
DR Pfam; PF04564; U-box; 1.
DR Pfam; PF10408; Ufd2P_core; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51698; U_BOX; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 586..659
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT COILED 129..156
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 665 AA; 77419 MW; F00AEE5EA1C09B91 CRC64;
MYSVLHSLLK SADSRMATLN YMSDVLRLNI KKTQLSTDNQ MSSDGFMLNV LSIMQKLSIK
IDVSKIDTMY PYHPDTRMVI GVDDSRINAS YQSVKSWIDS IAHPWTPPNF STECFFMTAQ
MHHLTILPMV RKQQRCQRAA RETQNLVNEL ERIESQWKNS ANAYRNIKLL KRWRSQVERL
TKSSLTMLVA LCDPQLVDRA FLFYSLLAKY LLVIVGATTP DGIQLLPQSS TAPMLFASLP
DYFIEDFADF FLFIVQNSPN LLANIWLEDI ITLIIVIICK SQFVSNRYLV AKLVEIMYIT
NPKVHPYGGR FSELIVNHHM SLDHLVPALM KFYSDVESTG ASSEFYDKFS IRYHLSIIFK
YLWEKPVYQA KVIEEASGPH FVKFVNMLMN DTTYLLDESM ETLKRIRELQ DLMDNKSQWD
KLGLEQQQSK QKLLAQEERQ CKSYLTLASE TVDMFHYLTE KVQDQFLIPQ LADRLAAMLN
FNLQQLCGPK CNNLKVRNPE KYSWYPKVLL SNLIDIYLHL DRSSLFPEAI ANDERSYSKE
LFDDAISRMV RTNIKTDTEV EQFANLQEKV EVIVVDKQKL EIDYGDIPDE FRDPLMDTLM
FDPVQLPSGT IMDRKVILRH LLNSQTDPFN RQPLTEDQLV SLPELKAQVM EWAKSRRHEQ
MKMKE
//
