ID T1GBS5_MEGSC Unreviewed; 633 AA.
AC T1GBS5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
OS Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC Phoridae; Megaseliini; Megaselia.
OX NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA000713-PA, ECO:0000313|Proteomes:UP000015102};
RN [1] {ECO:0000313|Proteomes:UP000015102}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Durham, NC isolate 2 -- Noor lab
RC {ECO:0000313|Proteomes:UP000015102};
RA Hughes D.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MESCA000713-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; CAQQ02034320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02034321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02034322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1GBS5; -.
DR STRING; 36166.T1GBS5; -.
DR EnsemblMetazoa; MESCA000713-RA; MESCA000713-PA; MESCA000713.
DR HOGENOM; CLU_432533_0_0_1; -.
DR OMA; ETHEACK; -.
DR Proteomes; UP000015102; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 6.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 7.
DR SMART; SM00135; LY; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF63825; YWTD domain; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS51120; LDLRB; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000015102};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 142..156
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 210..251
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 345..357
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 352..370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 386..398
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 393..411
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 405..420
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 425..437
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 474..492
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 510..522
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 517..535
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 529..544
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 549..561
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 556..574
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 568..583
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 593..605
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 600..618
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 633 AA; 70973 MW; 68AA4100F41D8709 CRC64;
MDGTMRETII STKIYWPNGL TLDITTQRVY FADSKLDFID FCYYNGTGRQ QVLAGSHYLL
HPHSLSLFED TLYWTDRQLN RVLSANKFQG KNQTVVSHLI SQPLSIHVHH PSLQPLHNNP
CEGSHCQHLC LLSPSSKTGF TCKCKPGYKL LDDGHCVEEE NPFLMVVKGS QIVDVPLNGG
DARAGSLTPK AIVDKDLSQP SGLAIDYDER KLYWTDAVRE KIERANLDGS NRENLISATI
YPFAISVFRN YIYWTDLQLR GVYRAEKHTG ANMIEMVKRL EDSPRDIRVY SKDRQKCSVN
PCHINNGGCA QSCHPAPNGK AECKCDDNSK LVNEGRTCAP RNHTCESSKF YCQNGKCISR
MWACDGDDDC GDNSDEEPNY CSYHSCSPNE FRCNNGRCIF KSWKCDHEND CKDGSDEVGC
TYPPCVDGEF TCTNGRCIPM AQVCNGVNDY DCRDNSDELP ENCPQCNPES DFKCANNRCV
PKQWTCDFSD DCGDGSDEVE TLCKGSYREC SESEFHCGNG KCISSRWRCD HEDDCGDNTD
EQNCEGYQCK NGTFQCASGH CIASYFRCDG DKDCRDMSDE VGCPPRYPGG RYCPESRFQC
NNNLCVSPSD LCDGTDDCGD GSDENPEVCS NFN
//
