ID   T1GD31_MEGSC            Unreviewed;       559 AA.
AC   T1GD31;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:MESCA001210-PA};
OS   Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC   Phoridae; Megaseliini; Megaselia.
OX   NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA001210-PA, ECO:0000313|Proteomes:UP000015102};
RN   [1] {ECO:0000313|Proteomes:UP000015102}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Durham, NC isolate 2 -- Noor lab
RC   {ECO:0000313|Proteomes:UP000015102};
RA   Hughes D.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:MESCA001210-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CAQQ02394105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CAQQ02394106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1GD31; -.
DR   STRING; 36166.T1GD31; -.
DR   EnsemblMetazoa; MESCA001210-RA; MESCA001210-PA; MESCA001210.
DR   HOGENOM; CLU_017959_5_4_1; -.
DR   OMA; GLGFDWN; -.
DR   Proteomes; UP000015102; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   PANTHER; PTHR11119:SF3; LD30822P; 1.
DR   PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015102};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        47..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        88..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        187..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        217..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        256..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        412..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        440..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        474..498
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   559 AA;  61129 MW;  AED768725725698F CRC64;
     MSPPENSVSN MEMSVVINPE NDEKIGNGKK LGERETNLLY GINENPPWYL CIFLAFQHYL
     TMIGAIVSIP FILTPALCMS DEDPNRGVII STMIFVTGIV TFFQATFGVR LPIVQGGTIS
     FLVPTLAILN LEQWQCPAPE VFNAMNEAEK EELWQIRMRE LSGAIAVSAL FQVILGFTGL
     ISKILRFVTP LTIVPTVSLV GLTLFEHAGN TAAKHWGIAV GTTAMLTLFS QILVNIEVPY
     PAYRKGHGIE WKTFQLFRLF PVLLTIILMW GLCGILTATD VFEPGHAART DVRIKVLTDA
     KWFYVPYPGQ FGLPSVTIAS VLGMLSGVIA CTIDQSATIQ QGIGIEGLGT VLAGLWGAGN
     GTNTFGENVG AIGVTKVGSR RVIQWAAFIM LLQGIIGKFG AVFIMIPDPV VGGIFCVMFG
     MICAFGLGTL QYVDLRSARN LYIIGLSIFF PMVLCKWIQN HPNVIHTGST TADAVLSVLL
     GTSILVGGFL GCFLDNVIPG TDEERGLKAW AKEMPLGGDD ETEDIETTDY DFPIGMNLMR
     KWKWTSHIPF MPTYKPKRS
//