ID T1GD52_MEGSC Unreviewed; 3362 AA.
AC T1GD52;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC Phoridae; Megaseliini; Megaselia.
OX NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA001233-PA, ECO:0000313|Proteomes:UP000015102};
RN [1] {ECO:0000313|Proteomes:UP000015102}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Durham, NC isolate 2 -- Noor lab
RC {ECO:0000313|Proteomes:UP000015102};
RA Hughes D.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MESCA001233-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; CAQQ02159899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02159900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02159901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02159902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02159903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 36166.T1GD52; -.
DR EnsemblMetazoa; MESCA001233-RA; MESCA001233-PA; MESCA001233.
DR HOGENOM; CLU_000038_7_0_1; -.
DR Proteomes; UP000015102; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 3.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 2.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015102}.
FT DOMAIN 673..822
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 970..1478
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1670..1822
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 101..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1935..1980
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2183..2266
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3362 AA; 383321 MW; BE80A4ADF5859C84 CRC64;
MVVWDKQVEV FREAQRILER QRFQFPNNWL HVDNIEGEWS AFNEIIKRKD SAIQTQVASL
QAKISAEDKA IETRTSDFLN DWEKSKPTGG KIRPDDALQQ LQLFESKYTR LKEERDNVAK
AKEALELQES AIPNNSSERM HVVLEELQDL RGVWSELSKI WVQIDETREK PWLSVQPRKL
RQQLEGMMTQ LKELPARLRM YESNMLIVEL KSDALKERHW KQLTKQLRVN WVLSDLTLGQ
VWDVNLLKNE SIVKDIILIA QGEMALEEFL KQVRESWQNY ELDLINYQNK CKIIRGWDDL
FNKVKEHINS VAAMKLSPYY KVFEEEALTW EEKLNRINAL FDVWIDVQRR WVYLEGIFSG
SADIKTLLPV ETSRFQSISN EFLGLMKKVS KSPKVMDVLN IPAVQRSLER LADLLGKIQK
ALGEYLERER TSFPRFYFVG DEDLLEIIGN SKNIGRLQKH FKKMFAGVAA IILNEESNVI
LGISSREGEE VKFIRPVSTV EHPKINEWLI MEWCDKYQAQ IVVLAAQILW SEDVEVALQQ
ASENPSAKPL NKVLQSVEST LNVLADSVLQ EQPALRRKKL EHLINEFVHK RTVTRRLINH
GVTNPKSFQW LCEMRFYFDP RNTEVLQQLT IHMANARFYY GFEYLGVQDR LVQTPLTDRC
YLTMTQALEA RLGGSPFGPA GTGKTESVKA LGNQLGRFVL VFNCDETFDF QAMGRIFVGL
CQVGAWGCFD EFNRLEERML SACSQQIQTI QEALKSQQDS NKESLSVELV GKQVKVSPDM
AIFITMNPGY AGRSNLPDNL KKLFRSLAMT TPDRQLIAEV MLFSQGFRTA ENWLAKFHYD
FGLRALKSVL VSAGNVKRDR IMRIKENKRQ QGETNIDEAS IAENLPEQEI LIQSVCETMV
PKLVAEDIPL LFSLLSDVFP NITYTRAEMK GLKEEIRKVC AEQYLVCGEG EEQGAAWMEK
VLQLYQISNL NHGLMMVGPS GSGKSTAWQV LLKALERFEG VEGVAHVIDP KAISKEALYG
VLDPNTREWT DGLFTHVLRK IIDNVRGEIN KRQWIIFDGD VDPEWVENLN SVLDDNKLXX
XXXXXXXXXX XXXXXXXXXX XLTLPNVQDL KFATLATVSR CGMVWFSEDV LSTEMIFENY
LLRLRSIPLE DQDEDFIGSA NKESKEDEIS PCIQVQREIA LLLQPYFSAD GIVVRCLEYA
MDQEHIMDFT RLRALSSLFS MLNQAARNVL EYNQQHQDFP MAPEQLEQYI PKSLIYSILW
SLAGDAKLKV RVDLGDFVRS VTTIPLPGIQ GTPIIDFEVN LQGEWVPWSN KVPVIEVETH
KVASPDIVVP TLDTVRHETL LYTWLAEHKP LVLCGPPGSG LNFSSATTPE LLLKTFDHYC
EYRKTPNGVV LSPIQIGKWL VLFCDEINLP DMDSYGTQRV ISFLRQLVEH KGFYRSSDQA
WVSLERIQFV GACNPPTDPG RKPLSHRFLR HVPIIYVDYP GETSLKQIYG TFARAMLRLM
PSLRGYSEPL TNAMVEFYLA SQDRFTQDMQ PHYVYSPREM TRWVRGICEA IRPLDSLPVE
GLVRLWAHEA LRLFQDRLVD DSERRWTNEN IDIVAMKHFP GVDREKALNR PILYSNWLSK
DYMPVNREEL RDYVKARLKV FYEEELDVPL VLFDEVLEHV LRIDRIFRQP QGHLLLIGVS
GAGKTTLSRF VAWMNGEDFD EDLRSVLRRA GCRDEKIAFI LDESNVLDSG FLERMNTLLA
NGEVPGLFEG DEYTTLMTQC KEGAQREGLM LDSSDELYKW FTQQVMRNLH VVFTMNPSTD
GLKDRAATSP ALFNRCVLNW FGDWSDSALF QVGKEFTLRV DLEKPSWSAP DFFPSVSPLV
PSVPTHRDAV INSCVYVHQT LHQANGRLAK RGGRTMAITP RHYLDFIHHF VKLYSEKRSD
LEEQQLHLNV GLNKIAETVE QVEEMQKSLA VKSQELQAKN EAANTKLKQM FKDQQEAEKK
KVQSQEISIQ LAEQTVKIEE KRKYVMADLA QVEPAVIDAQ AAVSSIKKKQ LAEVRSMANP
PAVVKLALES VCDLLDKPAS DWKTIRGIMV QDGFISSIVN LKTEDITKQQ LVEVRTMANP
PAVVKLALES ICLLLGENAT DWKAIRAVIM RENFINSMLY NFGTEDITDE VREKMKSKYL
SNPDYNFEKV NRASNACGPM IEYADMLKRV EPLRQELQSL EDQAEVNVKS AQDTKDLIAQ
LEQSIASYKE EYAQLISQAQ AIKTDLENVQ AKVDRSIALL KSLNIEKERW ECTSETFKSQ
MSTIVGDVLL SAAFIAYGGY FDQHYRNNLF STWCQHLQSA NILYRGDIAR TEYLSNPDER
LRWQANALPT DDLCTENAIM LKRFNRYPLI IDPSGQATTF IMNEFAGKKI TKTSFLDDSF
RKNLESALRF GNPLLVQDVE NYDPILNPVL NRELRRTGGR VLITLGDQDI DLSPSFVIFL
STRDPTVEFP PDISERPDID EKRSDLLKLQ GEFRLRLRQL EKSLLQALND AKGKILDDDS
VITTLETLKK EAFDINQKVD ETDKVIAEIE TVSQQYLPLS VACSNIYFTM DSLNQVHFLY
QYSLKMFLDI FSTVLYNNPK LEGMTDHTLR LATITKDLFL ICYDRVARGM LHSDRLTFAL
LMCKIHLKNT ASDQNLDQEF NFFLRSKEGI LSNSVHIEGL TAEQIEGVNR LAKRLSIFKK
LIDKVKSMPE IGAWLQQSSP EQSVPHLWDD AKALTPISAS VHQMLLIQAF RPDRVIAAAT
SVVSTCLGEE FMPTAEKEFD FAHVVEKQLN CSTPALLCSV PGFDASGRVD DLAVLLKNVH
LAPQWLVQLE KKLHSLQPHS GFRLFLTMEI SPRVPVNLLR AGRIFVFEPP PGIRANLLRT
FSTVPANRMM KVPSERARLY FLLAWFHAIV QERLRYVPLG WAKKYEFNES DLRVACDTLD
TWIDSTAMGR TNLPPEKVPW DALRTLLAQS IYGGKIDNDF DQRLLSSFLN KLFTARSFEA
DFALVANVDG AAGGPNGQRH ITMPDGTRRD HFLKWIENLA DRQTPSWLGL PNNAEKVLLT
TRGTDLISKL LKMQQLEDDD ELAYSAADES NETAASQPAW LELLPKNLPT LKRTVENIKD
PLYRYFEREV TSGAKLLCTV VADLQDVILI CQGEKKQTNH HRSMLSELVK GIIPKGWRKY
TVPTGCTVIQ WVTDFSNRVK QLQKVSQLVS QAGAKELQGF PVWLGGLLNP EAYITATRQC
VAQANSWPLE ELALDVSILE TGSNGDQKDS SFGVTGLKLQ GAQCKNNELL LASTIMMDLP
LTILKWVKIG SDLRTGKLTL PVYLNSTRSE LLFTVDLAVA AGQDPHSFYE RGVAVLTSTA
LN
//
