ID T1GFQ6_MEGSC Unreviewed; 1175 AA.
AC T1GFQ6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
OS Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC Phoridae; Megaseliini; Megaselia.
OX NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA002203-PA, ECO:0000313|Proteomes:UP000015102};
RN [1] {ECO:0000313|Proteomes:UP000015102}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Durham, NC isolate 2 -- Noor lab
RC {ECO:0000313|Proteomes:UP000015102};
RA Hughes D.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MESCA002203-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; CAQQ02096900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02096901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1GFQ6; -.
DR STRING; 36166.T1GFQ6; -.
DR EnsemblMetazoa; MESCA002203-RA; MESCA002203-PA; MESCA002203.
DR HOGENOM; CLU_003500_1_0_1; -.
DR OMA; CENENVT; -.
DR Proteomes; UP000015102; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:UniProt.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 3.40.50.2300; -; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF489; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000015102};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 679..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 740..1003
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1088..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 773
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1175 AA; 133287 MW; 93B4EA03D8E9FAA1 CRC64;
MLLYLYLTVN LPIVPSKSDK IYLLETQRSA HKAANAIYKI ILEEILNYTN VEIVNMTNKI
EQTTMLRHLS RSKQYNKPSL QISTALWNNP DEPIISDIAL SAGALTEPGK YGLFYATQFG
PIEFSMLQSP TEKDLKKFTL AEDVSPINIT DVDGRCANRT CIPVLGSDID KEQNIQNLIK
YENLSIQVLW LSNLTEVVDH LIKTNQPFIV LHWTPSEITM NFSSINLPSN KYYRFETTTI
GKYYRYYAYP NPEPFKVATK ALQFLKISKL DFFDLFQNPA NSTYSITCEI AKRCIPSTIQ
SYFHIGSIYP EDGTKLKDIF EKTVNVINNH SISDFSIELQ SKNGNCQADQ VLRHTIEYFN
AGIVDGILGP ACSETIQPIA GISRYLNIPI ISYAAEAPEF DQDKYPYFFR TIGSNGQYGD
VYIQFFKMFD WKRFATITEE GKKSTEYIIN MEKKSKTDSI ESIMDIKMTK QTNTSDIIDH
LQELKRRRVR VIIAHVRNEL IEVVLCEAYH LKMTAQYNYV WFLPSNPSTK SSRCTSEEIN
LALNGHFTYF QAATKLVAES PRAFESSDYR NITRFTELIR DSDFEGVTGR VRFGKGNSRI
TNITILQWSE DQYNVVGEYQ PNITGYKENM STETGTIYVN QSAIKWAGIP SDGTFDCKLS
MLVKMFGTDC ENENVTLEIL IIVFVFALIC AGLFWFVKRR YDNKLRESAK VMKNFGIDLL
APTTATYNTL DKWEVPKESI VINRRLGEGE FGTVFGGEAK FPHYDEWIAV AVKSLKCGAT
NESKLDFLSE AEAMKRFNHE HIVKLLGVSL QTEPVYTIME YMLYGDLKTF LLARRHMIHE
KINDDSDISP KRLTKYALGI AKALKDVACR NVLLSADRVA KLGDFGMARS MYENDYYRFN
RKGLLPVRWM APESLALSVF TPASDIWSFG VFLYEIITFG SFPYQGLTNR QALQCIVSKQ
ILTIPSDVKP QLEKLIKACW NQDAKYRPRA SDIISLMEQL PLLVSPCLDV PISSVELHEN
NEPINIDLLA KMGFKKLKSP VIAQMSTINN LDYTNTDANG MIIPMESMNV YPIEEEEDDV
VTELIPKSVA SSSPSSSSST SSSSYASSSS STANNSEAAS ELYTIETNND YCSMVPLLNN
NNSHDSNHNS THILDKPSNA TITQFSRLND VEHGH
//