ID   T1GFQ6_MEGSC            Unreviewed;      1175 AA.
AC   T1GFQ6;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
OS   Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC   Phoridae; Megaseliini; Megaselia.
OX   NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA002203-PA, ECO:0000313|Proteomes:UP000015102};
RN   [1] {ECO:0000313|Proteomes:UP000015102}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Durham, NC isolate 2 -- Noor lab
RC   {ECO:0000313|Proteomes:UP000015102};
RA   Hughes D.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:MESCA002203-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CAQQ02096900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CAQQ02096901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1GFQ6; -.
DR   STRING; 36166.T1GFQ6; -.
DR   EnsemblMetazoa; MESCA002203-RA; MESCA002203-PA; MESCA002203.
DR   HOGENOM; CLU_003500_1_0_1; -.
DR   OMA; CENENVT; -.
DR   Proteomes; UP000015102; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0007154; P:cell communication; IEA:UniProt.
DR   CDD; cd00192; PTKc; 1.
DR   Gene3D; 3.40.50.2300; -; 4.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR24416:SF489; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015102};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        679..697
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          740..1003
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1088..1115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         773
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1175 AA;  133287 MW;  93B4EA03D8E9FAA1 CRC64;
     MLLYLYLTVN LPIVPSKSDK IYLLETQRSA HKAANAIYKI ILEEILNYTN VEIVNMTNKI
     EQTTMLRHLS RSKQYNKPSL QISTALWNNP DEPIISDIAL SAGALTEPGK YGLFYATQFG
     PIEFSMLQSP TEKDLKKFTL AEDVSPINIT DVDGRCANRT CIPVLGSDID KEQNIQNLIK
     YENLSIQVLW LSNLTEVVDH LIKTNQPFIV LHWTPSEITM NFSSINLPSN KYYRFETTTI
     GKYYRYYAYP NPEPFKVATK ALQFLKISKL DFFDLFQNPA NSTYSITCEI AKRCIPSTIQ
     SYFHIGSIYP EDGTKLKDIF EKTVNVINNH SISDFSIELQ SKNGNCQADQ VLRHTIEYFN
     AGIVDGILGP ACSETIQPIA GISRYLNIPI ISYAAEAPEF DQDKYPYFFR TIGSNGQYGD
     VYIQFFKMFD WKRFATITEE GKKSTEYIIN MEKKSKTDSI ESIMDIKMTK QTNTSDIIDH
     LQELKRRRVR VIIAHVRNEL IEVVLCEAYH LKMTAQYNYV WFLPSNPSTK SSRCTSEEIN
     LALNGHFTYF QAATKLVAES PRAFESSDYR NITRFTELIR DSDFEGVTGR VRFGKGNSRI
     TNITILQWSE DQYNVVGEYQ PNITGYKENM STETGTIYVN QSAIKWAGIP SDGTFDCKLS
     MLVKMFGTDC ENENVTLEIL IIVFVFALIC AGLFWFVKRR YDNKLRESAK VMKNFGIDLL
     APTTATYNTL DKWEVPKESI VINRRLGEGE FGTVFGGEAK FPHYDEWIAV AVKSLKCGAT
     NESKLDFLSE AEAMKRFNHE HIVKLLGVSL QTEPVYTIME YMLYGDLKTF LLARRHMIHE
     KINDDSDISP KRLTKYALGI AKALKDVACR NVLLSADRVA KLGDFGMARS MYENDYYRFN
     RKGLLPVRWM APESLALSVF TPASDIWSFG VFLYEIITFG SFPYQGLTNR QALQCIVSKQ
     ILTIPSDVKP QLEKLIKACW NQDAKYRPRA SDIISLMEQL PLLVSPCLDV PISSVELHEN
     NEPINIDLLA KMGFKKLKSP VIAQMSTINN LDYTNTDANG MIIPMESMNV YPIEEEEDDV
     VTELIPKSVA SSSPSSSSST SSSSYASSSS STANNSEAAS ELYTIETNND YCSMVPLLNN
     NNSHDSNHNS THILDKPSNA TITQFSRLND VEHGH
//