ID   T1GR42_MEGSC            Unreviewed;       271 AA.
AC   T1GR42;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Vacuolar ATP synthase subunit S1 {ECO:0008006|Google:ProtNLM};
OS   Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC   Phoridae; Megaseliini; Megaselia.
OX   NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA006114-PA, ECO:0000313|Proteomes:UP000015102};
RN   [1] {ECO:0000313|Proteomes:UP000015102}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Durham, NC isolate 2 -- Noor lab
RC   {ECO:0000313|Proteomes:UP000015102};
RA   Hughes D.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:MESCA006114-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the vacuolar ATPase subunit S1 family.
CC       {ECO:0000256|ARBA:ARBA00009037}.
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DR   EMBL; CAQQ02142394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1GR42; -.
DR   STRING; 36166.T1GR42; -.
DR   EnsemblMetazoa; MESCA006114-RA; MESCA006114-PA; MESCA006114.
DR   HOGENOM; CLU_059623_0_0_1; -.
DR   OMA; HYLYKRE; -.
DR   Proteomes; UP000015102; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.160.110; -; 1.
DR   InterPro; IPR008388; Ac45_acc_su.
DR   InterPro; IPR046756; VAS1/VOA1_TM.
DR   InterPro; IPR046755; VAS1_LD.
DR   PANTHER; PTHR12471:SF4; AGAP001624-PA; 1.
DR   PANTHER; PTHR12471; VACUOLAR ATP SYNTHASE SUBUNIT S1; 1.
DR   Pfam; PF20520; Ac45-VOA1_TM; 1.
DR   Pfam; PF05827; VAS1_LD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015102};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        227..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          74..207
FT                   /note="V-type proton ATPase subunit S1 luminal"
FT                   /evidence="ECO:0000259|Pfam:PF05827"
FT   DOMAIN          221..259
FT                   /note="V-type proton ATPase subunit S1/VOA1 transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF20520"
SQ   SEQUENCE   271 AA;  30209 MW;  6F7B3FFCAF3F1BCE CRC64;
     NSSIHLDKDD YPKLAGILAS NRWSYLPQQN LPIEPFDYTS NLEIITLTGD YSQQDTEISG
     LYNDAVNTFG SGQVLAILAC KDGEGHYLYK REANDPKTTT SEPEKTEEDF VYISQDGKGI
     LYTTSALILH FNIFIRFNFT KSGGYWSLQA ANIDYNNAQI NSILPISRRS CLPEAPIGFS
     YRCSSSDLFF NGTDGNLTIK DFQVQPWTKD SSFSDAYNCV GFVTIPILSG LFICSIVIGI
     LSVGINLLMS IKTPTKFDNN RSKQLSFTVQ D
//