ID   T1GSQ5_MEGSC            Unreviewed;       475 AA.
AC   T1GSQ5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=K Homology domain-containing protein {ECO:0000259|SMART:SM00322};
OS   Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC   Phoridae; Megaseliini; Megaselia.
OX   NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA006716-PA, ECO:0000313|Proteomes:UP000015102};
RN   [1] {ECO:0000313|Proteomes:UP000015102}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Durham, NC isolate 2 -- Noor lab
RC   {ECO:0000313|Proteomes:UP000015102};
RA   Hughes D.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:MESCA006716-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; CAQQ02389986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1GSQ5; -.
DR   STRING; 36166.T1GSQ5; -.
DR   EnsemblMetazoa; MESCA006716-RA; MESCA006716-PA; MESCA006716.
DR   HOGENOM; CLU_023629_0_1_1; -.
DR   OMA; NMVQEMT; -.
DR   Proteomes; UP000015102; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   CDD; cd00105; KH-I; 1.
DR   Gene3D; 2.40.50.90; -; 2.
DR   Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR002999; Tudor.
DR   PANTHER; PTHR22948:SF78; MATERNAL PROTEIN TUDOR-RELATED; 1.
DR   PANTHER; PTHR22948; TUDOR DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF00013; KH_1; 2.
DR   Pfam; PF00567; TUDOR; 2.
DR   SMART; SM00322; KH; 2.
DR   SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015102};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          53..121
FT                   /note="K Homology"
FT                   /evidence="ECO:0000259|SMART:SM00322"
FT   DOMAIN          124..196
FT                   /note="K Homology"
FT                   /evidence="ECO:0000259|SMART:SM00322"
FT   REGION          209..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  53746 MW;  D3E79DB3E17E8547 CRC64;
     MLRAPTTPTL KLILGLGLCS LGGAMLYAYF KNKDDEDELE GSENDLVTQK PPREITIKMT
     VTNDCIPLVV GRNGANLKII EDRTGARIRF RELDSNNQQC EIRGTEKGVA DAKSMLMRDI
     QRSPIVKEEM YVPHSVYTKI IGRCGECLRD ICRTSMAKVS VESGDRVESK HPRKIEISGT
     KAQVNLAKKL IEDKIKEDEE MQRTFNEIEA KREPRRSPTN SMTSLSSSQT SLASIYPQKE
     KLPFGDVGDK PMEVYVSAIA SPSKFWLQII GPQSRKLDEL VTEMTSYYNE KENQEYHKIE
     DPYLDVVLDL YFVDYGDSEY VSPHDVYELR TDFLTLRFQA IECYLANVKP NLSTDVENWD
     QQAVSKFEEL TQVASWKKLI SRVVTYKARP KGGNHIRREG SPLPGVELYD PSEGVEVNIG
     HMLISHGFAE PDAPVNDVLR LGGGGGWRSP IELNGSNNNW HQFNGNEFTN RLKIL
//