ID   T1GUD7_MEGSC            Unreviewed;       607 AA.
AC   T1GUD7;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Chitinase {ECO:0008006|Google:ProtNLM};
OS   Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC   Phoridae; Megaseliini; Megaselia.
OX   NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA007347-PA, ECO:0000313|Proteomes:UP000015102};
RN   [1] {ECO:0000313|Proteomes:UP000015102}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Durham, NC isolate 2 -- Noor lab
RC   {ECO:0000313|Proteomes:UP000015102};
RA   Hughes D.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:MESCA007347-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. Chitinase
CC       class II subfamily. {ECO:0000256|ARBA:ARBA00009121}.
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DR   EMBL; CAQQ02196149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1GUD7; -.
DR   STRING; 36166.T1GUD7; -.
DR   EnsemblMetazoa; MESCA007347-RA; MESCA007347-PA; MESCA007347.
DR   HOGENOM; CLU_002833_3_1_1; -.
DR   OMA; AFCNING; -.
DR   Proteomes; UP000015102; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR   GO; GO:0004568; F:chitinase activity; IEA:UniProt.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006032; P:chitin catabolic process; IEA:UniProt.
DR   CDD; cd02872; GH18_chitolectin_chitotriosidase; 1.
DR   Gene3D; 3.10.50.10; -; 1.
DR   Gene3D; 2.170.140.10; Chitin binding domain; 2.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR002557; Chitin-bd_dom.
DR   InterPro; IPR036508; Chitin-bd_dom_sf.
DR   InterPro; IPR011583; Chitinase_II.
DR   InterPro; IPR029070; Chitinase_insertion_sf.
DR   InterPro; IPR001223; Glyco_hydro18_cat.
DR   InterPro; IPR001579; Glyco_hydro_18_chit_AS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR11177; CHITINASE; 1.
DR   PANTHER; PTHR11177:SF360; CHITINASE 12-RELATED; 1.
DR   Pfam; PF01607; CBM_14; 2.
DR   Pfam; PF00704; Glyco_hydro_18; 1.
DR   SMART; SM00494; ChtBD2; 2.
DR   SMART; SM00636; Glyco_18; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF54556; Chitinase insertion domain; 1.
DR   SUPFAM; SSF57625; Invertebrate chitin-binding proteins; 2.
DR   PROSITE; PS50940; CHIT_BIND_II; 2.
DR   PROSITE; PS01095; GH18_1; 1.
DR   PROSITE; PS51910; GH18_2; 1.
PE   3: Inferred from homology;
KW   Chitin-binding {ECO:0000256|ARBA:ARBA00022669};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU000489};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000489};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015102};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          18..359
FT                   /note="GH18"
FT                   /evidence="ECO:0000259|PROSITE:PS51910"
FT   DOMAIN          476..524
FT                   /note="Chitin-binding type-2"
FT                   /evidence="ECO:0000259|PROSITE:PS50940"
FT   DOMAIN          553..607
FT                   /note="Chitin-binding type-2"
FT                   /evidence="ECO:0000259|PROSITE:PS50940"
FT   REGION          416..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   607 AA;  67978 MW;  DE2480D9C3C55AE7 CRC64;
     MKNFTIIFLG ILTLTEGSII LCYYGSWSSY RSGDGKFSTD NIDPFLCTHL VYAFFGLSPN
     GSIQSLDSYL DFTLGLENLA AVGGWNQGSG LYSTVAASPT LRKNFIDSSI AFLENYGFDG
     IDLDWEYPAQ RDSVNPSSDK ANFVTWLQEI KDAFQSYGYM LTIAVAAAES SASLSYNIPE
     ISEQVDYISL MTYDLHGSWN WLTGINAPLY STDGFNVDAC VTYWLQQGAP PSKLLLGVPF
     YGRTFTLENE ANNGIGVPTL GPGNAGEYTK ESGFLAYYEI CTGSWNHVWS NEQSVPYAYS
     GNQWVGYDNP ESIRLKVEYM SSKGLAGIMI WSIETDDFLG KCGSVNPLLN VINDDFFNGF
     NYNDNINFNS FNNFYNTYNN NSCNFHLNNN SYNYHFNNNY SCNYNYHSVN NYSATTTTTP
     STTPATTTTT PSTTPATTTT TPSTTQTTTT LSTSTTTKEP STTKKVVTPA NVNYTRIDCD
     ALGEGFYRDP YDWSLFYKCE DGQQFYFLCQ TGMLFDDVNK VCDYYYLVDP SLPITTISSQ
     ETTNTPRIIP FVDIGCGTLP EGFYRDPDDC SIYRVCTKGE QYDFYCQEGL YFDTKKEVCN
     FDYIVDC
//