ID   T1H809_RHOPR            Unreviewed;       931 AA.
AC   T1H809;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=CUB domain-containing protein {ECO:0000259|PROSITE:PS01180};
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC000144-PA, ECO:0000313|Proteomes:UP000015103};
RN   [1] {ECO:0000313|Proteomes:UP000015103}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:RPRC000144-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   EMBL; ACPB03006880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACPB03006881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACPB03006882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACPB03006883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1H809; -.
DR   STRING; 13249.T1H809; -.
DR   EnsemblMetazoa; RPRC000144-RA; RPRC000144-PA; RPRC000144.
DR   VEuPathDB; VectorBase:RPRC000144; -.
DR   eggNOG; ENOG502QU8S; Eukaryota.
DR   HOGENOM; CLU_003797_0_0_1; -.
DR   InParanoid; T1H809; -.
DR   OMA; PECPRKQ; -.
DR   OrthoDB; 3024709at2759; -.
DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   CDD; cd00041; CUB; 1.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR   Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 3.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR47537:SF8; CUB DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47537; CUBILIN; 1.
DR   Pfam; PF00431; CUB; 1.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00042; CUB; 2.
DR   SMART; SM00192; LDLa; 2.
DR   SUPFAM; SSF57424; LDL receptor-like module; 1.
DR   SUPFAM; SSF49854; Spermadhesin, CUB domain; 3.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015103}.
FT   DOMAIN          53..167
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
FT   DOMAIN          196..341
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
FT   DISULFID        15..27
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        22..40
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   931 AA;  103442 MW;  8B3A940DCA298C8C CRC64;
     MFAVFIAMFT LVGACRISEL TCRNGKCISL DLYCNGNNDC GDNSDEPKYC TVCNRTYYGD
     LGRTYSMNLR APREDRLPYL CHLTFTANGN DNGDIVQLIF DVFNVGRYDG GCPDGYVQVT
     ELGRPLTEGG WCGQAAGPSL YYSESTTITL SLRLIHNSPF RVDLRYKFLG TVEAVTRLGT
     VDVPIERGVH VPGSYCGRTF DECYRSKCQI QSPNFPGMYP RNVTCHYHIW QKTVPTCKHA
     MIGIKDNYVR LRRSVLAGLN KTAKYTKVDC TPLEDQLLFY DGQDEDAPLM VRYCGGGLLP
     RVVSRSSHLL VVFKSSPYGV PLLTTQTPKP LHGFQLIVDV LFSDSDSLDF AKGTNYTFHF
     PNTIEPPCEF LVNGTKTRRG EVLSPRHTLP PNTSCHYRLS GLNTDRVWLY FDSYTLPATS
     PSNCSTRLKL YDQANVLEDT CGTPRLCDHS SLRNSSRETR PCKKPESYIT PYGKLSIVHR
     SDEGTALQPV TFKFHYEFVD TRLGGESSKT GAPCHRLFRK RKSGLVHSPK NVFMFGRGGA
     KNLTCVYRIE SSSGERVRLS IHNASFGSHG CKTISDSHTS RPICVRSGRS VELAVSDMPW
     RDIRLQRACY CDNSVLSRTS AGPTVFLSSG RVLEISFAVT SFNVTEDYND IYFHASYQMV
     RWAECSRQQR LTGSGGEIGL VFPAKQKDDV YCEGTPWLVE ATGNKSLFLL TWGHFLPLDS
     VSDSCHTTNR VLLYTGDPLR LMRVVCPSLE KEKEFAVHVF SEEWFGGSAW SRTPPSFLVE
     FVGREAGNAY LNWLEISKSK SFSAKQVDNG TSWECKHRCP ELNACISPGL YCDGYHNCPS
     GFDEENPDCG VTTKLLSALT PGRILILSVS VGAALILLTA LGFVLVCCRP CGSSGSTKRT
     RQSQHCRSRC SSSSRGGEAL LASNSSTISS S
//