ID T1HCF6_RHOPR Unreviewed; 1221 AA.
AC T1HCF6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Insulin receptor substrate 1 {ECO:0000256|ARBA:ARBA00015710};
DE AltName: Full=Protein chico {ECO:0000256|ARBA:ARBA00033282};
OS Rhodnius prolixus (Triatomid bug).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC001720-PA, ECO:0000313|Proteomes:UP000015103};
RN [1] {ECO:0000313|Proteomes:UP000015103}
RP NUCLEOTIDE SEQUENCE.
RA Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:RPRC001720-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2015) to UniProtKB.
CC -!- SUBUNIT: Bindings to phosphatidylinositol 3-kinase and SHP2.
CC {ECO:0000256|ARBA:ARBA00011440}.
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DR EMBL; ACPB03004429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1HCF6; -.
DR STRING; 13249.T1HCF6; -.
DR EnsemblMetazoa; RPRC001720-RA; RPRC001720-PA; RPRC001720.
DR VEuPathDB; VectorBase:RPRC001720; -.
DR eggNOG; ENOG502QUNU; Eukaryota.
DR HOGENOM; CLU_275873_0_0_1; -.
DR InParanoid; T1HCF6; -.
DR OrthoDB; 4212441at2759; -.
DR Proteomes; UP000015103; Unassembled WGS sequence.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF13; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Differentiation {ECO:0000256|ARBA:ARBA00022943};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Oogenesis {ECO:0000256|ARBA:ARBA00022943};
KW Reference proteome {ECO:0000313|Proteomes:UP000015103}.
FT DOMAIN 14..115
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 129..237
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 237..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..900
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1221 AA; 133768 MW; A9E798E9B6663C59 CRC64;
MTSRNSAVKV SSRDIVKQGY LKKLKTMKKK YFVLRRDSAE VPARLEYYDS EKKFKANLAP
KRSITLKTCF NINKPSDTRQ KYVIALFTKK DRFCVVFDNE DEMEDWLKVL LELQHEGNLP
AGEPARPNFE QVWQVTVLSK ELGQRANILG PHRLCLTDQT LSLVKLSTTH PDQVDAIKFS
LQKIRRCGHV DSFFYMEVGQ CTVTGAGNLW MQTEDNNIAE NMHAIILKAC GNCTKKDLQP
KSRNRSSSAN EASKPVSLMQ RWPTHTGLTG VRERSDSMPS RARTTSECAP SHMHPPRYVT
TSQYRPHSMY NRGVSYSPPV GSSPVSPASA ACSTDSAGSS LSMDGDSTDC PWEDQGRYGH
SLTPDEPVIL EENPDDYSPW IGEDEKLNNY MPMDTNYCLP IQSNPSFNSS VYRKYSPNPS
SSGFKSSSPS QASFMEMYSP CGSSPMDTPG NYLPMSPGEN RLQNYTKNVG NHSRGSSLAE
DGYVPMAPGA SDDGYVDMDH GPRRNKQERY QSGDLSTGSS CSITSGTPSN DFRFNEYPSD
KVPYYFTHEE DITPAERPAR AYSVGSRPTY NNNRSEIASS SAERTRAFSV GSKNVRVANP
MRMVMHNHNP ATHASSHSSM EPSDDMMELD FSKKGRMKSC KKPSSSERLS VPVGSASTLS
SLASSYSTAE GSYMDMSLPC SSNSASVAPS PPKPSRFAAL LGKSPPKPSL QEVHALNKSS
PPVSGYPSPS LGRVPETEPG YVEMTIKSDS QSTTPSDHCL CMTHSESKDD AYVEMKPGQI
EVKQIIATNA KARIDSFPPT NNQKMQGKLD STSLIFHNSN KEDYYDVTLK RKIPLIEDNN
NSKVISTGRP PSPSDYVVMD LGGKSPSNNC NESKQDSSNQ NYMNMSYKKE DKKKTRRDAR
YSSQPITIQS STKDSPNLVY TRAGRKHSTG TPPKVPSFLP LGRTGSPLSS PYSSLSRSKY
KEGVRKDNNT GPCSFVVHSP SELMDCYEQS PKVPIDGTSG TLKISYSETN LMEKRSEAKI
IQESSDYVDY QPCTCSSTSN DTSVDDYVPM APAATSSSKK PSRKTSAPSL GARIRPIEKL
LSGLGNSFST LSISSTPIVT LPPSPVKSES ETLVGDDAMG YSDDEGEGTA SKSGNSDSSR
KSSVASVGNK EIHYASLDLV VRSGGSIDGE ELSRNLTTQT SLSETSSTSI PSPNLSAVDT
TFNYAEIDFA KSGSSTQKTI H
//
