ID   T1HL23_RHOPR            Unreviewed;       501 AA.
AC   T1HL23;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=RUN and TBC1 domain-containing protein 3 {ECO:0000256|ARBA:ARBA00030864};
DE   Flags: Fragment;
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC004747-PA, ECO:0000313|Proteomes:UP000015103};
RN   [1] {ECO:0000313|Proteomes:UP000015103}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:RPRC004747-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the small G protein signaling modulator family.
CC       {ECO:0000256|ARBA:ARBA00006296}.
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DR   EMBL; ACPB03020756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1HL23; -.
DR   STRING; 13249.T1HL23; -.
DR   EnsemblMetazoa; RPRC004747-RA; RPRC004747-PA; RPRC004747.
DR   VEuPathDB; VectorBase:RPRC004747; -.
DR   eggNOG; KOG2222; Eukaryota.
DR   HOGENOM; CLU_051509_0_0_1; -.
DR   InParanoid; T1HL23; -.
DR   OMA; LESKCHP; -.
DR   OrthoDB; 12479at2759; -.
DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   CDD; cd17688; RUN_SGSM3; 1.
DR   CDD; cd11813; SH3_SGSM3; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
DR   InterPro; IPR035969; Rab-GAP_TBC_sf.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR035833; SGSM3_SH3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR47219:SF20; GTPASE ACTIVATING PROTEIN GYP2; 1.
DR   PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   Pfam; PF02759; RUN; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00593; RUN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF140741; RUN domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 1.
DR   PROSITE; PS50826; RUN; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
SQ   SEQUENCE   501 AA;  57569 MW;  1DBAFFA7CFF9C758 CRC64;
     GIQADQRVLR TLICSFLPDV DVTLKQHDIE LSLITLHWFL TIFASVVHMK ILLRIWDMFF
     FDGSIVLFQI TLGIGLENSA QIFNALSDIP GEIDDVEQLL QVSLEVGSSL TDVVIETHRR
     RHLAYLMTDQ GALVGNPESA PNLPKQHLTR RQVKKSKSVI QLILFGDEIT EDDIKSKNIR
     QTELLVDLRE SILQVARHFL TTEPKLCKDT ALIADYSIES HTKDHEQYLN VSRTRNRRAK
     ALLDFERNDD DELGFRKNDV ITIISQNDEH CWVGELNGLR GWFPAKFVEV LDERSKQYSC
     AGDDSVSEAI TDLVRGTLCP AMKQVLEHGM KRPHFLGGPC HPWLFIEEAA TREVERDFNS
     VYSRLVLCKT YRLDEDGKVL TPEELLYRCV QAVNLTHDNA HAQMDVKLRS LICLGLNEQV
     LHLWLEVLCS CLEVVQKWYH PWSFVSSPGW VQVKCELRIL SQFAFNLNPD WELPAKKQPS
     QPLKDGVRDM LVKHHLFSWD L
//