ID T1HLF6_RHOPR Unreviewed; 456 AA.
AC T1HLF6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:RPRC004880-PA};
DE Flags: Fragment;
OS Rhodnius prolixus (Triatomid bug).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC004880-PA, ECO:0000313|Proteomes:UP000015103};
RN [1] {ECO:0000313|Proteomes:UP000015103}
RP NUCLEOTIDE SEQUENCE.
RA Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:RPRC004880-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the tRNA nucleotidyltransferase/poly(A)
CC polymerase family. {ECO:0000256|ARBA:ARBA00007265,
CC ECO:0000256|RuleBase:RU003953}.
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DR EMBL; ACPB03010982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1HLF6; -.
DR STRING; 13249.T1HLF6; -.
DR EnsemblMetazoa; RPRC004880-RA; RPRC004880-PA; RPRC004880.
DR VEuPathDB; VectorBase:RPRC004880; -.
DR eggNOG; KOG2159; Eukaryota.
DR HOGENOM; CLU_015961_2_0_1; -.
DR InParanoid; T1HLF6; -.
DR OMA; NLCPKPM; -.
DR OrthoDB; 5402987at2759; -.
DR Proteomes; UP000015103; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001680; P:tRNA 3'-terminal CCA addition; IEA:UniProt.
DR CDD; cd05398; NT_ClassII-CCAase; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3090.10; cca-adding enzyme, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002646; PolA_pol_head_dom.
DR InterPro; IPR032828; PolyA_RNA-bd.
DR PANTHER; PTHR46173; CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR46173:SF1; CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR Pfam; PF01743; PolyA_pol; 1.
DR Pfam; PF12627; PolyA_pol_RNAbd; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81891; Poly A polymerase C-terminal region-like; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW RNA-binding {ECO:0000256|RuleBase:RU003953};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003953}.
FT DOMAIN 74..195
FT /note="Poly A polymerase head"
FT /evidence="ECO:0000259|Pfam:PF01743"
FT DOMAIN 230..281
FT /note="tRNA nucleotidyltransferase/poly(A) polymerase RNA
FT and SrmB- binding"
FT /evidence="ECO:0000259|Pfam:PF12627"
SQ SEQUENCE 456 AA; 52569 MW; 063605993F2E195B CRC64;
LMYTFLKRGS QLLMKLESSY AILRGSNSLR EYSLNNIKKT PFTMKIDSPE FRGIFSPGLQ
TLLDIFERHR YEIRIAGGAV RDVLLGQHPK DVDFATTATP DQMKEMFIAE DVRMINMKGE
KHGTITARID NENFEVTTLR IDVVTDGRHA EVKFTTDWEL DANRRDLTIN SMFLGADGTL
YDYFGGYEDL KNRRVLFVGN AKKRIQEDYL RILRYFRFFG RITESPDFHD KDTIVAIKDN
IEGLEKISGE RIWQELSKIC SGNFVGSIIQ KIIEVGAAPY IGLPVDPNIN ELKCVWERGK
NLNMHPLTIL ASLLNSEQEM MALHARCKFS AFERELGLFI VEHRKINSNS DNPLRPYQAL
MYKTDNKLSD TRAHIIELFK YKADLALLHE FKTWEPPKFP LSGNLLKEHG VPAGKPFGKV
MKELKLHWIE TDFKIDQDGL IELLPKVMQE LNIKTK
//
