ID   T1HP38_RHOPR            Unreviewed;       769 AA.
AC   T1HP38;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
DE   Flags: Fragment;
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC005812-PA, ECO:0000313|Proteomes:UP000015103};
RN   [1] {ECO:0000313|Proteomes:UP000015103}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:RPRC005812-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2015) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; ACPB03014848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1HP38; -.
DR   STRING; 13249.T1HP38; -.
DR   EnsemblMetazoa; RPRC005812-RA; RPRC005812-PA; RPRC005812.
DR   VEuPathDB; VectorBase:RPRC005812; -.
DR   eggNOG; KOG2166; Eukaryota.
DR   HOGENOM; CLU_004747_7_1_1; -.
DR   InParanoid; T1HP38; -.
DR   OMA; MFKDMTI; -.
DR   OrthoDB; 21270at2759; -.
DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          383..637
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   769 AA;  89189 MW;  9684BA1F998FD07C CRC64;
     IKMMKSGLPK KEGKMRIRAF PMSMDEKYVE SIWGLLKSAI QEIQKKNNSG LSFEELYRNA
     YTMVLHKHGE RLYTGLKEVV THHLETKVRE DVLRSLNNNF LQILNQAWND HQTSMVMIRD
     ILMYMDRVYV QQNDVDNVYN LGLIAFRDQV VRYGCIRDHL RETLLGLVAR ERKGEVVDRM
     SIKNASHMLM VLGINSRCVY EEDFERPFLH QSAEFYKMES QKFLGENSAS VYIKKVEARI
     NEEAERAKHY LDESTEGFIV EVVETELIKK HMKTIVEMEN SGVVHMLMNQ RTEDLACMYN
     LFSRVSDGLK TMSDCVSLYL REQGKALVEE QQPNTNAITY VQVSYDDFSA LLDHFLHNSF
     NNDKIFKHMI AADFEHFLNL NSKSPEYLSL FIDDKLKKGV KGMTEQEIES VLDKTMVLFR
     FLQEKDVFER YYKNHLAKRL LLNKSVSDDS EKNMISKLKT ECGCQFTSKL EGMFKDMTVS
     NTIMEEFKEH ITTTGANLCG VDLSVRVLTT GFWPTNNATL NCNIPAAPHS AFEVFRRFYL
     GKHSGRQLTL QPQLGSADLN AVFYGTRREE EEGGPPVSSS TNAHLTSQPR KHIIQVSTYQ
     MCVLMLFNKR DRLTYEELQH ETDIPEKDLI RALQSLAMGK ASQRILIKTP KTKEIESAHV
     FYVNDAFTSK LHRVKIQTVA AKGESEPERK ETRSKVDEDR KHEIEAAIVR IMKARRRMPH
     NVLVTEVTEQ LRSRFLPSPV VIKKRIENLI DREYLSRTSE DRKVYTYVA
//