ID T1HQC3_RHOPR Unreviewed; 1474 AA.
AC T1HQC3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Glycogen debranching enzyme {ECO:0000256|ARBA:ARBA00020723};
DE EC=2.4.1.25 {ECO:0000256|ARBA:ARBA00012560};
DE EC=3.2.1.33 {ECO:0000256|ARBA:ARBA00012778};
DE AltName: Full=Glycogen debrancher {ECO:0000256|ARBA:ARBA00031477};
DE Flags: Fragment;
OS Rhodnius prolixus (Triatomid bug).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC006247-PA, ECO:0000313|Proteomes:UP000015103};
RN [1] {ECO:0000313|Proteomes:UP000015103}
RP NUCLEOTIDE SEQUENCE.
RA Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:RPRC006247-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2015) to UniProtKB.
CC -!- FUNCTION: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-
CC alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase
CC in glycogen degradation. {ECO:0000256|ARBA:ARBA00003530}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in
CC glycogen phosphorylase limit dextrin.; EC=3.2.1.33;
CC Evidence={ECO:0000256|ARBA:ARBA00000927};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Transfers a segment of a (1->4)-alpha-D-glucan to a new
CC position in an acceptor, which may be glucose or a (1->4)-alpha-D-
CC glucan.; EC=2.4.1.25; Evidence={ECO:0000256|ARBA:ARBA00000439};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the glycogen debranching enzyme family.
CC {ECO:0000256|ARBA:ARBA00025780}.
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DR EMBL; ACPB03023891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13249.T1HQC3; -.
DR EnsemblMetazoa; RPRC006247-RA; RPRC006247-PA; RPRC006247.
DR VEuPathDB; VectorBase:RPRC006247; -.
DR eggNOG; KOG3625; Eukaryota.
DR HOGENOM; CLU_001517_2_0_1; -.
DR InParanoid; T1HQC3; -.
DR OMA; ALFETWV; -.
DR OrthoDB; 1427975at2759; -.
DR Proteomes; UP000015103; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004134; F:4-alpha-glucanotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004135; F:amylo-alpha-1,6-glucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102500; F:beta-maltose 4-alpha-glucanotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0005980; P:glycogen catabolic process; IEA:InterPro.
DR CDD; cd11327; AmyAc_Glg_debranch_2; 1.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR010401; AGL/Gdb1.
DR InterPro; IPR032788; AGL_central.
DR InterPro; IPR029436; AGL_euk_N.
DR InterPro; IPR032792; AGL_glucanoTrfase.
DR InterPro; IPR032790; GDE_C.
DR InterPro; IPR006421; Glycogen_debranch_met.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR NCBIfam; TIGR01531; glyc_debranch; 1.
DR PANTHER; PTHR10569; GLYCOGEN DEBRANCHING ENZYME; 1.
DR PANTHER; PTHR10569:SF2; GLYCOGEN DEBRANCHING ENZYME; 1.
DR Pfam; PF06202; GDE_C; 1.
DR Pfam; PF14701; hDGE_amylase; 1.
DR Pfam; PF14702; hGDE_central; 1.
DR Pfam; PF14699; hGDE_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycogen biosynthesis {ECO:0000256|ARBA:ARBA00023056};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 26..100
FT /note="Eukaryotic glycogen debranching enzyme N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14699"
FT DOMAIN 103..535
FT /note="Glycogen debranching enzyme glucanotransferase"
FT /evidence="ECO:0000259|Pfam:PF14701"
FT DOMAIN 681..931
FT /note="Glycogen debranching enzyme central"
FT /evidence="ECO:0000259|Pfam:PF14702"
FT DOMAIN 1028..1473
FT /note="Glycogen debranching enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06202"
SQ SEQUENCE 1474 AA; 167368 MW; F42F8A327BD7920F CRC64;
LELNKGENRE KELFRIRKDY QVRLKEGPSL YGCNVRVYTN LPEFSEQKFE RSQYRLVKDG
VLLADRAGSF HYYFVIGTSD SRNDAAGEGY ILVEPNLTLN GEELPLDCIQ CVTVLSKCLG
PMSTWNDRLS IAVQSGYNMV HFTPIQQRGK SNSAYSINDQ LSIDQSFAEG PFQTRPTMEQ
VGNFMENLRK EHKVLSICDV VLNHTATEAE WLQSHPECAY NLMNTPHLRP AYFLDRLLKD
FSKDIANGMY DTCGLTAEIE TEEHLQALRH QLNSVILPAA KIAEFYTVDI KKLVAEFSDR
CYKSEPARNP AVRDECRLKV IQDPLYERLK STVDLELAVN SYNIYRSDCF DEDTRKRKCT
ESFKKRLEQL NDVIQKEIDD HLQAAVENIV ANVRYFRVQN DGPKLGVVTA KSPLVARYFV
DWKATSEDAM FNNYEGAFIM AHNGWVMDHD PLQDFAQPGS NVYLRRELIP WTDSVKLRYG
DKREDCPYLW DRMDRYVSET ARIFDGIRLD NCHSTPIHVA QYLLDSARAI KPDLYVVAEL
FTNSDLTDNV FVNKLGITSL IRECMSAWDS HEVGRLVYRF GGWSIGSLSP PRIAAAKIAH
ALFMDQTHDN PSPVKVRSVF DLLPSSALVC MAACAVGSTM GYDQLVPHQV YHLFSKLVKF
NRELQSSIVY MHKKDCNENV GISHGKRALN KLHYNLAREG FNQVFVDQVD REIVCVTRQN
PRTLDSVLLF AHNSFGWPDC STENGGIGKG ITVDGIAHSV ILEAWLKRII NQFKKNPNYI
NGLDEYKLEL KEGITVEECT MARIAPCGHT STRIDLTKAF KPGSVLAIRI INRTNAREAA
AKLYRDIHKE FLDQALQNLN LIHMNHILYK CSEEEEGGSY DVPNFGKLVY CGLQGIMSVL
EKVFKNEDIG HPICDNIRNG PWLGEYTVNR LKRVRATSKL GQLIEENLKL VEQLPRGYRP
WGIYRVLSQV YQAVIRSLML LMSDFIKNGD EFTKELALIS IQMCGAVASA PLPPLSERIS
PPKLDARKPS VTLAAGLPHF ATGYMRSWGR DTFISLRGLL LITGRFDEAR YLILGYGACL
RHGLIPNLLN GADLNPRYNC RDAVWWWLHS IKEYCKMVPD GYNILNEPVN RLFPNNDAEK
PEFQVSTEQI LHDVMQEALN AHFQGLCFRE RNAGLAIDQH MTSNGFDNQI GVHPKTGFVF
GGNQWNCGTW MDKMGSSNEA GTLGRPATPR DGAAVEIVGL SMAIVSWLDS VSPHQYPHIG
VTRVTKSGET ISWTWEDWVN RIKSNFETEF YIPLEERRDT KNENDKYVHK RGIYKDTCGA
SQPWSDYRLR PNFLVAMVVA PNLFSPSNAR TSLDTASILL GLLGLKTLDP DDLAYCGNYD
NSNQSSDFRV AHGYNYHQGP EWLWPTGYYL RSLLKTCEHS SDSVEKTRKW LGRLWSTLRS
SDWHGLPELT NENGAHCPDA CPTQAWSAAS ILEV
//