ID   T1I3N8_RHOPR            Unreviewed;       787 AA.
AC   T1I3N8;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
DE   Flags: Fragment;
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC010907-PA, ECO:0000313|Proteomes:UP000015103};
RN   [1] {ECO:0000313|Proteomes:UP000015103}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:RPRC010907-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|ARBA:ARBA00010663, ECO:0000256|RuleBase:RU000688}.
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DR   EMBL; ACPB03012339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1I3N8; -.
DR   STRING; 13249.T1I3N8; -.
DR   EnsemblMetazoa; RPRC010907-RA; RPRC010907-PA; RPRC010907.
DR   VEuPathDB; VectorBase:RPRC010907; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   HOGENOM; CLU_009579_25_1_1; -.
DR   InParanoid; T1I3N8; -.
DR   OMA; KERRHIA; -.
DR   OrthoDB; 2952147at2759; -.
DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   CDD; cd15302; 7tmA_mAChR_GAR-2-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR   PANTHER; PTHR24247:SF191; MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A; 1.
DR   Pfam; PF00001; 7tm_1; 2.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 2.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000256|RuleBase:RU000688};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          55..765
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
SQ   SEQUENCE   787 AA;  85270 MW;  FF719A304DB1281A CRC64;
     NSTLVDTVAN TSELYDNLTT STADVLTPVL PPFELWQTVL IAICLGLCII LTVGGNILVL
     MAFIVDRTIR QPSNYFIASL AATDMLIGTV SMPFYTVYVL MGYWNLGPIL CDLWLSVDYT
     VCLVSQYTVL LITIDRFCSV KIATKYRGWR TKNRVIWMVT ITWIIPALLF FISIFGWEHF
     VGFRDLLPGQ CAVQFLKDPV FNTALIIGYY WTTLVVLFVL YGGIYKVAYD MQKKSEAKQR
     KMQSMVALSA GAMSGMAGRA AGIGLSKTQS TLLSQDKPKT TTAPSTTTST TTAPTSLTVA
     ASTHSGGDSS SSQKTSSKTG TSNTEITSST EKKKHQSGEG DKSERSSSPA FESDEDSTTC
     TTEKNTTYSK KKPSLAGMVA QTGALNMFAP SKVNGVIPKT TEQVKPSTPV DVPPLPQIPE
     ATLLDTDTPG AQSTKTLTPI LGNRDLSKSD KSSDKSLSEM STPPISIQSP PSIIPPPSMF
     QSSTPASGCS PLSVGRPRSL IMIKNTYDIL TGMDNSDLRY MDESSVIVPT PNFESPPSTM
     SFPNTSSTAP PSPVHNSMTV SNTSLLQAAL IRAAAQQVAN NTPPKVSTPP ITKVNTEVSL
     SGEDKAITSI VETAPDPETT VVDKLVGTPA TLYSTASNSI ATVQNVITAP PTPDPRKEST
     RTTRSSSDRK DSSRRDFVKT IGKRLKGKGR SSGGSRQKSK SENRARKAFR TISFILGAFV
     ACWTPYHILA LVEGFCANPP CTNEHLFMFS YFLCYANSPM NPFCYALANH QFKKTFTRLL
     KGDFHMT
//