ID T1IHY4_STRMM Unreviewed; 597 AA.
AC T1IHY4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Peptidase M12B domain-containing protein {ECO:0000259|PROSITE:PS50215};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR000464-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR000464-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR EMBL; JH430051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1IHY4; -.
DR STRING; 126957.T1IHY4; -.
DR EnsemblMetazoa; SMAR000464-RA; SMAR000464-PA; SMAR000464.
DR eggNOG; KOG3538; Eukaryota.
DR HOGENOM; CLU_457347_0_0_1; -.
DR OMA; PCANAIN; -.
DR OrthoDB; 3042901at2759; -.
DR PhylomeDB; T1IHY4; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1620.60; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR InterPro; IPR041645; ADAMTS_CR_2.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF251; PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF17771; ADAMTS_CR_2; 1.
DR Pfam; PF01421; Reprolysin; 2.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500}.
FT DOMAIN 226..466
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT REGION 199..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 66973 MW; E5B210658134E6F7 CRC64;
MHIPLFTPHP SSGHRFRQFP QKLPLRHDAS SAQHTHLIAP PDRGTNSVPE YEAAKVTLHH
INRRHLSEFG SNRPDYHLLA VVETAKTTMH LHLRRRNDIV ASTFEIEVHH LNYTEVITAD
QLALPVCLYH GRVKQGGQAA VSTCSEIGMV GLIILEETHY ILQPIPPRLL NIVGVSHIMY
RKTDPHFCPH KFDTTMVAPE ENADDQNQID ESDKNSRTRR ASSATKVIET AVFVDDVMYT
SVKKEFKNDP TKAIRDVVFT MINAVQLLYN QPNLNRKFNF VLVKIGILAS ASVPSKAEGD
IKNYLLNFCK WQNDKNPGND RNSKHWDNAI MLSGLNLYQG SPSNHRVIGL AWVSGMCKST
YSCCINEGNN FETVFVISHE LGHKRKKGAV VYLSKTGQTR LYRHAVVSEG IRLGMHHDGD
SNKCSGDTHI MSPSLGPGKI RWSSCSKKYL DDFVKKKSSS CLSDSGTVLA DLNHVSAGGL
PGERFDINDQ CRKAFGKKYT PHLASKKPFD SVCRELWCMG EGYVKRAHPA LDGSTCAKNK
ICKYGDCITD DRSSSQRGKS KAKGNWHEEA TTKPTTFWGK VKGKAQQVWD KMKSWGR
//
