ID   T1IK21_STRMM            Unreviewed;      1175 AA.
AC   T1IK21;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=Rho GTPase-activating protein 100F {ECO:0008006|Google:ProtNLM};
OS   Strigamia maritima (European centipede) (Geophilus maritimus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX   NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR001256-PA, ECO:0000313|Proteomes:UP000014500};
RN   [1] {ECO:0000313|Proteomes:UP000014500}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA   Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA   Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA   Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA   Muzny D.M., Gibbs R.;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:SMAR001256-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2015) to UniProtKB.
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DR   EMBL; JH430389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1IK21; -.
DR   STRING; 126957.T1IK21; -.
DR   EnsemblMetazoa; SMAR001256-RA; SMAR001256-PA; SMAR001256.
DR   eggNOG; KOG1452; Eukaryota.
DR   HOGENOM; CLU_003464_0_0_1; -.
DR   OMA; GLTEEMY; -.
DR   OrthoDB; 2905108at2759; -.
DR   PhylomeDB; T1IK21; -.
DR   Proteomes; UP000014500; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00030; C2; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR   PANTHER; PTHR46150:SF3; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014500}.
FT   DOMAIN          193..263
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          725..841
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          877..1073
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          87..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          457..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1099..1139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1102..1137
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1175 AA;  132138 MW;  F0FC831C89F68165 CRC64;
     MAAAPLGDML FCRVMTSARH KRASSWSTCS HHHGVGVCGS KFTIFSYAPP CYAVGGESDV
     TCTPPLWQKI LSQSIDRIGG LFPFQESREG TSTEMSSPGR AAGAARATRV RVPPPEMVMQ
     SDFRKVSGIS TEIFNQIQAV ENDHDATTAA SLEAVERRGE MMVRILDIRN MGRSAAEQAK
     RFLLPDPNFI VRFVEIVKRP GQTLGLYIRE GNGMDRHDGV FISRIAIESA VANSRCLAVG
     DEILAVNLVD ITRVSLDDVV IMMSIPRRLV LATKSRKHGK GPRMAKAIER VGPPVVVIKK
     ELEELEPEDV SNSNGENGAM LYPPQPYATI HLGEPVGSPY LAEEQYLYYN SQPHLKYQQP
     LMEHDPWLTQ PGPSGYQRVV FEQPKALPQA QYPKTLESLA EQVHTFYSAP HGAPTIHSRT
     LQPSRSERAL ARRAATTGRM LRAESDHRLA SSLTDRPYTT GRVRPLRPSL KVPGPTCATL
     PLHHRRPPPP VHRLNVYSHR SDGAYSDTEA MTMPAVSILS RPQDHRAKSY ASRSNSLPRM
     RTDDRFHRRH RHTVRFEKDI HDSQDESDGA LSAPELPMRR ERVRIPSSPS VFTAAEYRAW
     LNRAPSTSAI YEKLKKSREV LHAQKSARVT YSAENLLDRR REDQGFSYHT YRRPLSRTSQ
     DQLTGGTLSR RVRYLLDEAQ NIPHPTPAKP SDFKMHLLDI NPAEFLKYRP EREPLPTPAE
     APVTPVPTPS PSSLMDIKLF SGLLRVHLLA GRGLKHSGRS ERYRDLYCVL ECDHVHKART
     VVRTGEQNFD WDEIFDLDLI CNRELDFLIY SWDPQFRHKL CYKGSVDLYS LLSEGPVHQL
     ALKIEPRGTI YLKLRFTDPQ QAFRRALNLR KGSLFAVHLE TVVNRESASS GLNVPLLVKR
     CIEEVEGRGL DIIGLYRLCG SSSKKRMLRD GFERNPLAVD TSPDNVPDIN VITGVLKDYF
     RELPEPLITQ CLHQMLMDAF SVCIPEDPDG NAKLMFSILD CLPKVNRCTL ILLMDHLKLV
     VSQSDRNKMD AQNLALCFGP VLLVHSDPNS SITDFHKPVQ VLKYLLEIWP SKQQGENFWV
     FFNMAVLMGA VTSFIESSGG DESSQKLHDN HCQPDQPTLD SEQVERKENE SPEEHSGVIR
     TPFKSALRGT LLAIATEGAV TLVMENVVII SQVEK
//