ID T1IMB0_STRMM Unreviewed; 3206 AA.
AC T1IMB0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=P/Homo B domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR002108-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR002108-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
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DR EMBL; JH431009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 126957.T1IMB0; -.
DR EnsemblMetazoa; SMAR002108-RA; SMAR002108-PA; SMAR002108.
DR eggNOG; KOG2513; Eukaryota.
DR eggNOG; KOG3525; Eukaryota.
DR eggNOG; KOG4469; Eukaryota.
DR HOGENOM; CLU_225449_0_0_1; -.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 6.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR049452; Anoctamin_TM.
DR InterPro; IPR013579; FAST_2.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR013584; RAP.
DR InterPro; IPR014848; Rgp1.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF23; FURIN-LIKE PROTEASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF04547; Anoctamin; 1.
DR Pfam; PF08368; FAST_2; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF08373; RAP; 1.
DR Pfam; PF08737; Rgp1; 2.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00261; FU; 9.
DR SMART; SM00907; GDNF; 2.
DR SMART; SM00952; RAP; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51286; RAP; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1451..1475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2340..2365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2377..2395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2447..2472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2493..2513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2533..2556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2672..2695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3185..3205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 834..973
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT DOMAIN 2029..2086
FT /note="RAP"
FT /evidence="ECO:0000259|PROSITE:PS51286"
FT REGION 548..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2887..2909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2950..2970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2955..2970
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 538
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 577
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 758
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 3206 AA; 362655 MW; 421908ED88A0D9FC CRC64;
MIEVTARLIR GSVYLAGETI ECLITFRNPV INPNTRAQSN NEVCETLAWA SAQIHCQCSV
NDSKVQFPLT NSISQEELAT NNKETSFAPC KGERGHAVLS TKPKILFCDV RLIPGEKKTF
IYKDVIPMDV PPSYKGQAIK YSYKITIGTQ RVNCPIKLLR VPFKVLVVQG LIEANLYSDA
DDLLPSNPFL TSQQTEPTLD LAMQLLQNVT TRRNPSCYCI TNTYGRVVKF CLFKPAYKLG
EDIVGTFDFS TATVPCVQVF NLNNFSVTLQ SEETISDECR LKAYHGQSVV SYNKYHEFCL
HTKHTQMILP IPLSITPAFT TEIVTLKWKL HFEFVTTTTS IGNQQFETDT STSSTWSGPS
VLDIETMIWD LPIKIYPTNP IQVSYICMSL CDYDVYMNQF AVNINGDDKK ADEIAAKHGF
LNHGQIGSLE GYYLFEHNHV SKRSTDRNEE HHEKLMNEKE VLWVDQQKTL TRVKRDINYP
GVVRFFGFRT PYNGEFPDPM YSKQWYLHQG ASDGWDMNVL GAWRKGYTGY GVVVSILDDG
IQTDHPDLMK NYDPGASTDI NGNDADPTPQ DNGDNKHGTR CAGEVAAVAF NDVCGVGIAF
NASIGGVRML DGTVNDAVEA KALSLNRHHI DIYSASWGPE DDGRTVDGPG PLARRAFIDG
VTQGRNYKGS IFVWASGNGG RHVDNCNCDG YTNSIFTLSI SSVSQRGLKP WYLEECSSTL
ATTYSSGTPG HDKNVVTVDM DPSFRRETMC TQDHTGTSAS APIAAAISAL ALEANPNLTW
RDMQYLVVLT SRPEPLMKEE GWVTNGVKRK VSHKFGYGLM DATAMVNLAE QWISVPNQHI
CETEEDKHPR TIPRSMGDNL EIYMNTDACW NSPNVVNFLE HVQCRITLHY NPRGNLKIML
ESPLGTRTNL LSSRPKDMYQ ADFQDWPFLT VHFWGEKAAG QWKLTIVNAG TIDANEDGIL
KKWSLVFHGT EQHPIHLKSH PGRNPFPYAP VGRSADPMTE EDSLFEDCHK ECRDGCYGNG
AEKCKACRHL QTDTEPRYLH KFLYGWSIHD SNKTCRQCNS VCNGCVGDIN NCTECRTGLV
MSHNECLKCH STCETCMGPS PFDCVTCPAN LVHQNGSCSE SCPPGYFLHG HMNECYSCDP
FCETCNATQC LTCRSNCVID NEGKCRLKTE CSKGNFLKDD QCSPCHLSCD SCEGPNYSQC
LTCSTYLVLY KNVCTKKCPS NSVLIGNECQ ECHETCLKCS GSKSNQCLSC KRGLVLKNGV
CSTVCGEKLF AADDLCLPCH HSCLTCSGPL DTDCISCGSN LQLGDGKCQQ SCPFGSFPRN
SSCISCHHTC LNCKGDALYD CLSCQDNYVL DNGLCMECQR GMFYDRVSQK CKQCDTSCTT
CNGPDHLSCL SCTQPLKHDP VHHRCVPCCK NEFDQVCCVC DPRTDTCTSE IKRRIVAFSD
SVESDDDNAQ FPLLTFCVVA VATCIGLIIG FLVVYKILRQ FGYRYSCCSS NDYQPVPTRF
ETSDLHICQE NLLYGNLKGL KLNNGSSNIA YKTSQEVEVN EPNKSKKEND YAHAIMEKLD
KYSGYLAITN QIESPESAKW KISEEEISKT CKNVTNLSDS EIENILAILC QQTEHKETSK
SILTALDQEC IVRLLVWDVR TSLRMADYFY HLNVSRLLMY NYRMISHLIG RIRSLNSSEI
IQLLFYINVQ RECDLKVMVA VENELLKRLP QFSSEEVSIA ALAFFKTKNS LKSKNLVKMM
QQKFISDLDK LPDPAVSAFG KLFRFQRTAD PALLLEVLDK SLPYITKWKP SACLNVGLIT
LSRQLEHEEY VKSTALKFLN NLSVLRVKEL SHLLTCVSTY DYHLDFAPDF YSLLIAELRK
PEMQTQLMEH PLYLPLCLLG LAYHEIFPED LIQQALNPDF FNLVESKMKY GQRREYLMLD
STVEIELPNY SGPRLDPTTK RNLWQADRAS IPSITNRNLS IFEKTLLTLK YQLSDLLGGL
NYASILFVLP HFKLPEIVIH LDENKHPLST NHLRTSHSHI TAEKNVKSIC FTLTGRNSYA
ENTKKRLAHV KMKHRQLELL GYHVIEIPWF DYFVLDKTQR LNYVKKKLLP EKSRMKETDL
LTSRKKSYFP GRMSLRRRKI GAKIAFAKEG FGKSFQSSSD LMNPASLWMQ TIPTENCDVL
LTFPSKCENS TIMWVLSCLR TRLPQLDVRV RHHATSKTYG FYMTTNFENL LKGAEEMHMR
KHLKEEYGGG LKEFIADGQK CFEGVENSKE FFSSLERQSI VLHLLHSLRA IVSDSVGNVK
FVEGQAIIPK CVSEGIISQV LPLHKEELVE QLRLNWVRAF FKTQPLDAVC EYFGVKIAIY
FAWLGHYTSA LIIPAAFGLF LWIIFHGRNQ VIDDACFVLF AFLNVLWSSL YLISWKRYCA
ELTYRWGTYD DGNELLVEPR PLYTGDLEPS KVTGRPEPCY PAWKRNLFRY CISLPVIIFF
LSIVLVVMLA MFRFQEIWDK MLIKHEYPFF LTYVPKISLA LVISILDTVY QKVAVWLNNQ
ENYRLEETYE NHLILKIVVF QFVNSFLSLF YLAFYLRDME KLREQLAALL ITRQVIGNIR
ESFVPFMLEQ FKLAFMSFEM FGAFSPDNDN KFPNLDDILD LNDGGIPENG KDEASTSSKT
QNARNLSQAE VESSLYPYDG TFEDYLEMFI QFGYVILFSS AFPLAALCAL LNNVIEIRSD
AFKLCCIFQR PFGQHVKGIG TWQEAMEAMC VIAVIVNCAL IGMSGQVHRM FPDQSTNGTI
ILIVVLEHIT LTLKMAICRS IPDTPHWVAT EMAKVEFNRR EAVKKLVRTE ASAVLRSSSA
IIPLPLNPVK STDAQSQTEE TDLSQLDVPY RVLPLETSKA LSRKLTERIR KTSRKVKNRL
NSRRMLRNSF DKSEEGCENG IDENTEVKDE PGKSKKFLLK RIEANFRRLS SGSPSGNAFL
NMFSRKSSGQ KYMKMKRSSN EDSDEKSQLE STRRTVAEYC DVARAKCHFR DGCGLALRNY
MFDCADMMAG RTARCSESCS RALIALMSTE EGQLLVGCDC GDNEFCTQSK QRVEVCRPLV
TGAMEKSAVV SCSVAHWICK VDSLCNTALA YYHRFCRSMI HGRKCTPRCN NSIAILNRQE
KADKLRTCFC DGSEEYDCNS IKRNMQHLCF KKRNIFKVKN THVKGSSTTV GSVITVASCS
CRVCLSSSLL FIFMLFVVFL VIFTCK
//
