ID T1INM7_STRMM Unreviewed; 835 AA.
AC T1INM7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR002611-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR002611-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; JH431190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1INM7; -.
DR STRING; 126957.T1INM7; -.
DR EnsemblMetazoa; SMAR002611-RA; SMAR002611-PA; SMAR002611.
DR eggNOG; KOG4641; Eukaryota.
DR HOGENOM; CLU_009970_0_1_1; -.
DR OMA; NEMECEI; -.
DR OrthoDB; 5397075at2759; -.
DR PhylomeDB; T1INM7; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..835
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004579366"
FT TRANSMEM 600..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 652..788
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 835 AA; 96101 MW; 7B54673752963538 CRC64;
MFDWSKYLST AFCLCFCLIT VYCKLHKCVD IQVYGKKAFD SLDNSCTCNQ SSKNNIYLIE
CSEKWNSQPF TIEINAEKMI VNGSHGTIPF KFIEEFVPLV LSKMATIFKS LEISHFCNDA
STGNQLDLSN LVTDDDRNTT QIKMPYNCLQ SITSSRNEIG HFEQLDFSFN KLTQIPKLSY
NMYKLSNYDL SHNSIETISN TDFDITECVK FVNLSHNNLR LLPQNVLNNL QWLIDLDMSY
NELTKLPKYI FRQSYELEVI NLSHNRIKHV DLEFGIVCPL KVLRLESNDI IDFNIDGAGC
SNNPKIILSH NNISHVHVRL SYNHISHVNF SHNNITHVNL TELELQTIYR DKKIHLDFSF
NPFVCDCKLN KFIKYLKRNQ TETLLTFHDE NNICSSPSNL NGTPLVSIDD NLSCNYSKNC
PKSCHCTIDD IDNIAFVSID CANSNLTHFP NIASYGSSSV DIQLDLSRNA ISSLPSKSHP
MWTRIKKLDL SHNRIDSLEN MTDLSILTTL YLNDNSFREF DPRQLQVGRV KLANNPWECN
CVMSILVLQS SSIEDKNRMT CVKNETIMYN FTNVDQICSD NSIVYANFTQ IETIYEDKKI
LLVVILPIVV IVILISVIVI LFIKYKSEIV YYMFSKGICL KFVSEDDIDA DKVYDAFVSY
SGEDEDWIRD FLVPGLEARN PKYNLCLHNR DWLAGEFITD QIVKSVQTSR RTIIVLTDNY
LKSPWSRLEF DLAYQQGLKD QVRRVMVIVP NEVPDLSQID ATFKTFISLT TYIQANKPHF
WSKLRASMPR TSTQNKRKSS TLRKSVYLNS DSSQNLHHEE VVTTTSKCET NMTIV
//
