ID T1IRA1_STRMM Unreviewed; 438 AA.
AC T1IRA1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR003587-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR003587-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR EMBL; JH431342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1IRA1; -.
DR STRING; 126957.T1IRA1; -.
DR EnsemblMetazoa; SMAR003587-RA; SMAR003587-PA; SMAR003587.
DR eggNOG; KOG2624; Eukaryota.
DR HOGENOM; CLU_010974_0_0_1; -.
DR OMA; DGEHVDC; -.
DR OrthoDB; 3259424at2759; -.
DR PhylomeDB; T1IRA1; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR InterPro; IPR025483; Lipase_euk.
DR PANTHER; PTHR11005:SF100; LIPASE-RELATED; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid degradation {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR000862};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..438
FT /note="Lipase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004578727"
FT DOMAIN 73..133
FT /note="Partial AB-hydrolase lipase"
FT /evidence="ECO:0000259|Pfam:PF04083"
FT ACT_SITE 209
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 380
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 411
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ SEQUENCE 438 AA; 50156 MW; E485C8E3BF606B2F CRC64;
MKSQLLLLIF LAPSLNSEKC QTSQTIDDLQ KILQVETILK EENILSIEEI ENDYRASVKT
FFPAIDPEAF MNVTEIIKYH GYPVEEHIVE TSDGYVLKIQ RIPHGKNGLK MGPGKPVLLQ
HGLLASSVVW VTNTPDKNLA YLLADAGYDV WLGNIRGTVC GYNNTNFSPN DKRFWQFSFD
EMAKYDVPSV IQTVLKVTKY KQIYYVGHSM GTTMLFALLS SQPEYNNIIK AGFTLAPVTL
THNIRGALRV LSHFLTEVEW IYKFLQNGKF YLPPIIADFL ARTLCDSPLR VICENTMFLL
SGFDYAQTNA TRLPVHVYHT PDATSLQTMT HYAQLITASH FQYYDYGTTE NWHHYNQSTP
PIYNLSKITT PISIFWANND YLADPTDVTQ LVSQLKNVSL VYEVPFSKFN HLDFMWAIDV
KPLLYNKLLD ALQKQWTE
//
