ID T1ISE3_STRMM Unreviewed; 1743 AA.
AC T1ISE3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR004012-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR004012-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
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DR EMBL; JH431430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 126957.T1ISE3; -.
DR EnsemblMetazoa; SMAR004012-RA; SMAR004012-PA; SMAR004012.
DR eggNOG; KOG3523; Eukaryota.
DR HOGENOM; CLU_239624_0_0_1; -.
DR OrthoDB; 12272at2759; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11793; SH3_ephexin1_like; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845:SF5; EPHEXIN, ISOFORM D; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1305..1495
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1528..1650
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1661..1722
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 135..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 894..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1002..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..769
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1002..1030
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1743 AA; 195520 MW; AE892A1B9CE5CBA8 CRC64;
MPELMAIVTE RPRPKPRASL RLSSNQNIQQ YPLYQNLLYI SDVANNGSKL CESPCNRAVV
KPKPRRRSLL DPPILEERKF DENLEFSVRE KNDPLDQNLN VENCNCILSV CNGDKWGADS
ESNKLNEKTT DRFQPIKCMP YNSPRLRKAS RGSNSTMQRS REVKSSALPR AVGTNSKTSG
HNMETLGKRV QGVTSKNIPS RSERGAVSTF TQLRKSSFRK MEEVSNAKDN DSVKSQSDYR
RRVGSVTKDV DKRKSAAIPP QMVANLANKF NAMISENHKV PGASVDTGRK RVNSKGPSVL
SIQSCPSSPL RSNLTLINRR ESNARDAIVS KLAQKNNVKK EEINKKIQKT SIPTSCPSKA
SSPKISAPRA GSPKPASSPK AGSPKPASSP KASSPSAIRR KSFVQQAVLN YEVCVSASSS
PEIKRRNSLP KRTVSSLADE KSRVDTFASP VLLRRLLQSA ADVKASKFTS EFNHERRQST
DTQVNQRFNQ QEMPKTGGGR SEGRIAATGF SQNSSLGREG RVLQTPLTKD CIELIKQNAS
ESAMKTSIIT TSQLGSSKTD QNTSLSAADF YSESAKCEKV TNATVSALAR GRQLFDKRVS
GGVNDKKIDY AANLINRAPP PPLPTTQPRQ INNRTSMRRN NSCVKSVHLT DENKVQCLKN
VQSSYLHSNL IDNVCDKTQS NTTNSGGNKS ADLKVTNESA NYKSSFLHSL NVEEAHAKLN
ETSSASIEKK LMIEKTNYVP NTSFLWRQKN AATPYGSIPP PPNSAPPPIP EQNEDQKDCD
NIYDDVVSPC SDEFYDEPVY TEAQISPQNN LQINMAEIIT NNESDEGWVD VSDTEMEGNG
HKEMLSLPVN TRAKNMCWKN VQKRNSISRR ASWCQDEIKH DSSKVPMNSA AEDYADFDDD
FSGSDESNST NPDHHYEAVY KLNRDRFKAA PKHDQDLSAD CILEESPCET ENKEFASRCS
LASESRAIDL KEKRLKRNWS LTKSDIRLEL TSRLNKIRIK KTSTSATDVH STKFSRKNSD
PSSPTKKSPS PKKESALFYV PNCISSNETS EESARNVISI VAMQVGRRSS RSNVVRPRDA
PPAPPIRAIP KHRAESVSSI ESKRTSISSD WEIVQENDNY SRFSGSINSS RNVESDTEST
RSGTQSNDVD AKISSKAAVS RSSSTVSSES EVPILLSTSP KISKFVSRSS KSSCTNISTS
DYEEESEVTL RHFHTAMSPF NDEPLYQFYN IDARKRATQM NLLDDSDEEI YEAIYEVEKN
PVLKSELTAM DLLGPGETSQ RSLWGELSEV RNSGILNKIT PHQRGIQEAM FEVITSEASY
LKSLNVLVHH FMNCPQFKDA SLSDCALTKQ EWKILFSDVL PVKAVSEKLL ADLEKRWQEN
VMMEEICDIL LDHASKNFSV FIKYCSNQLY QDRTLKQLKE KNIQFVEVLK KLESSPKCQS
LAMHSFLMLP MQRITRLPLL IDAIFNRLTK GTMQYINCQM ALKKVNSIVQ ECNEGARKLA
RMEEMVVIAQ SLNFRDIKNV GIVSVSRWLV KRGALQKLTN QEFSSKFGFN VRRMAKQTIY
LFLFTDHLLI TKKKGEESYH VLDHCPRNMV QVSEINHTEQ LPARPPDGCK YLFKLTMLQN
CENKTVEMIL SALTESDKAR WVEAVTPKIS ENPDEKIYEA WDCPQVQAVH PYTAQESDEL
TIEESDAVNV FRKVADGWYF GERIRDGSQG WFPGNYTNEI LSAHVRARNL RQRYRLLEGL
SEQ
//
