ID T1IT80_STRMM Unreviewed; 4687 AA.
AC T1IT80;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:SMAR004324-PA};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR004324-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR004324-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MRE11/RAD32 family.
CC {ECO:0000256|ARBA:ARBA00009028, ECO:0000256|RuleBase:RU003447}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; JH431471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 126957.T1IT80; -.
DR EnsemblMetazoa; SMAR004324-RA; SMAR004324-PA; SMAR004324.
DR eggNOG; KOG2310; Eukaryota.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_0_0_1; -.
DR OMA; FFQSCAK; -.
DR OrthoDB; 166463at2759; -.
DR PhylomeDB; T1IT80; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0008296; F:3'-5'-DNA exonuclease activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.30.110.110; Mre11, capping domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR003701; Mre11.
DR InterPro; IPR038487; Mre11_capping_dom.
DR InterPro; IPR007281; Mre11_DNA-bd.
DR InterPro; IPR041796; Mre11_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00583; mre11; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF04152; Mre11_DNA_bind; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01347; Mre11_DNA_bind; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003447};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003447};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759,
KW ECO:0000256|RuleBase:RU003447};
KW Exonuclease {ECO:0000256|RuleBase:RU003447};
KW Hydrolase {ECO:0000256|RuleBase:RU003447};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|RuleBase:RU003447};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254, ECO:0000256|RuleBase:RU003447};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nuclease {ECO:0000256|RuleBase:RU003447};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003447};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500}.
FT DOMAIN 293..463
FT /note="Mre11 DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01347"
FT DOMAIN 2006..2145
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2644..2791
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 528..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1403..1437
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 538..552
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4687 AA; 535330 MW; D3A82351B5D22C7D CRC64;
MSDSNQASAD TFRILIATDN HLGYAENDAV RGKDSIVTFE EILSQAKRLK VDFILLGGDL
FHENKPSRTC MHSCLRLLRK YCLGDDPVRF QLVSDQNENF KHNTFRVVNY EDPNINISIP
IFSIHGNHDD PAGGGQLSSM DILSVSGLVN YFGKCLDLED ISITPLLMQK GRTKLALYGL
GSIRDERLHR AFVANKVKML RPSETTDDWF NIFVLHQNRS RHGLTNYIPD NFLDDFIDLV
FWGHEHECRI DPEPVGTKSF CITQPGSSVA TSLCSAEAKS KHIGLLEVCD KEMRVTKIAL
ETVRPFYFDD IILKDTGLDL SQGNVTDKVM GYCSARITEM IRKASLEHSG NENQPKQPLI
RLRVEYEDTN EMFSHHRFGQ KFIDQVANPK DMILFQRKRI TDPRKDNDGL DEEAFNLAYR
LENLEVGNIT AVDLVKEYFE NAEDNNKMLL CAEKTFGEAI QEYVEKEERE AINEYVKYQV
KKCQDYLKTK MKSNEDDVDK YIDNYRYEYN ATNDEAEMRE VIREARRKSN ANPLSDDEEI
MSNDDEVDEE ELEEVPVRGR GRARGRARGA RSRTTTRGST RRPTERAPRA RGGRGRAARG
SVASTPDVSS LFDARLSRTG TRSGTVLSGG SQASKRARLH ATRKGVNFSD EDSDIDTFIQ
FQDKAKAKHR VQRRFHLQSM LDLMNHQLFI KYKNHISRKR CHPPIMQSES WTKSAPFKEK
RQFRLVSDSI GNAFSQSAKN LTLRNLPQRK DVPELTAAAA NSSLTKFHYA RREMNFARRT
HKHLKLASIP PPSVRYPPSP PMSPMHQRNV MIRIEAQMES KTIPLTEHDL ECYNFYINNR
ISSDMVDPIP DYVLKKIDQR ISPKLKQRRM QQLILVDLWE EVKNDYKLSV RKAIMDYVLL
DDDEKRRINI PSSPPIFPVR MIRGPSPWHF GFQFTKNELT KVEFTTNPII RTINKIWMDK
FRLTKFINME DFPESQLPMS VESFESTVTA YVHKTTNLLI KEWIPQCAQV FTDQLSDWAP
FVPQGRDGSL TKVQRFFECV AALMSTQLRK MVTCTFVDFV NFLLIYEHGN NFNGDYHDLL
FFRQNILKIK VFVKEKKICF DPTLDDVLKL IERIFQLIIS CNQNIPRVEK ELFPEMKDQP
LFLRSVDFTE EHIQELYIKS VKIFKANLVG PQKYLNEYKK YLNLMDGQAE KKVLKFLDDK
SLTLKHYGKK IAEIAATRDE IIEGRYSVHL NLFGLATANV ISVLAGHAER LRLLVLDYIV
NTNREKNKEI CAAFEEIAQK AGETPTTTET IVNLASFMDD CEKKKLVKLK ADIGVSALNL
LFLLEHGMIS PEDTQLNNKV FNWMSDVKKI MDVCQTYLVS RREQVEESLH KRVRLYDDKL
VVLNKELETF KKKDPPILSI DEIKKNAENI ARIARTLDEA DQEVKAMNRE EILLEESPTV
FPAIQQMMTL KDPYEKLWTT AWTFVQNYDK WFNGPFLDVP AEAVAEEVEN MLKTLSKLIK
VFADQPGPRR VNDNIRARIE RFKVYVPLLL AICNPGMKKR HWDQISKHAG VDVKTTSKTT
LADMVELGLA KHVVKLDEIS SGASKEHAME SLLRRMKADW SDINLEFVTY RDTPIYLLVQ
VDDVQTMLDE HILKAQTMRG SPFVKPFEDE MINWENTLVT MQDIIDSWLK CQATWMYLEP
IFSSPDILKQ MPQEGRKFLY VDKQWRDITS KATLDCRALA LPAIDNLLPR LQECNRYLDE
IQASLNEYLD KKRLYFPRFF FLSNDELLEI LSETKDPLRV QPHLKKCFEG IHLLEFNHKL
EICGMISAEG ELIPYTRTIY PADFKGSVEK WLVEVEAEMI NSLRTITAAA VVSYPKSVRH
DWIIDWPGQI VLCTTMIYWT TDVEDAITRG NLQEYGDICT SQIDKVIALV RGKLNWGARI
TLGALIVIDV HARDVVVDLA GLNIQSVNEF DWTCQLRYYW LDDTVNVRMI TTSRNYGFEY
LGNSGRLVIT PLTDRCYRTL LGALQLNLGG APEGPAGTGK TETTKDLAKA LAKQCVVFNC
SDELDYKAMG KFFKGIATSG AWACFDEFNR ISLEVLSVVA QQILCITIAK NLKAKRFIFE
GSEINLNSGC AAFITMNPGY AGRQELPDNL KVLFRPVAMM VPDYGMIGEI SLYSMGYVNA
RSMAGKIINA YKLCSEQLSS QNHYDYGMRA VKAVLTASGN LKLKYATENE AILVLRAIKD
VNLAKFLDQD VDLFQGIITD LFPGIVLPVP DYELLYLALD ECILARNLQG TPWFIEKIIQ
VYEMVLVRHG LMVVGDPLGG KTSAYQLLAE SLTMLNSRGQ MGENKTIYRI LNPKAITMGQ
LYGQFDPNGE WCEGILSNTF RDLASNPTPD RKWILFDGPV DAVWIENMNT VLDDNKKLCL
MSGEIIKMTS SMSLIFEPED LEMASPATVS RCGMIYMESY KLGWRPFRDS YLNTLKDIMS
EELIQMLFDL FEWLVPPSLQ FIDKHCKQFV STSNMHIFKG MCNLFTCTLD YIEFTDPAFE
EYLPEQIVTW LQMLFVFCLG WGLGGSLTRE SRKKFDVFLR PILSGNDQAN PKPKSYRLTK
IQLFPERASM YDYAFDRRGI WVDWMETIPK ADLVIPPTAK PSGLIIKTNE MARQVFFLHI
LLNREIPLLF VGPTGTGKSA IINNCLLNLP QDKFMINTIN FSARTTASQT QDMVMVKLDR
RRKGLFGPTL GKKCVVLVDD LNMPAKEKWG AQPPIELLRQ WLDHWHWYDK RDTTKIELID
LNFVSAMAPP GGGRNDITKR MTRHLNIIAI DSFSDVTMIK IFSQIVDWHF AQGFESGVSI
TSKSVINATL DIYKKAMVNF LPTPTKSHYI FNLRDFSRVV LGVLFIPNTH LVDSAKVCRL
WIHETYRVFY DRLTDDNDRQ AFFAAITDTC KVAWKQSIDK ILHYLLVPPA TAITDADLRS
LIFGDFFHPD SDVKIYDEIR NIEALIEVME SYLAEYNAIS KSPMPLVMFR FAVEHISRVS
RILKADNGHA VLVGIGGSGR QSCAKLATFI SRFELFQIEL TKTYSMTEWR EDMKKLLKMA
GADGKKSSFV FADSQIKDEG FLEDVNMILN TCDIPNLYAS EEKVEILEKV QSAARDAGIQ
KEMTSMMVYN YFLDRVRANL HVCLAMSPIG DSLRLRLRMF PSIVNCCTID WFTVWPADAL
ERVAEKFLDE VELEANVKKK CTVICKGIHE SVIVASKRFL DMLRRHNYVT PTSYLELILT
FKKLIGLKTD EIDTLKNRYV GGLQKLEFAQ SQVSIMQDEL HALQPQLVIT SAETEKLMIK
IEQDTVAVEA TKEVVAADEA VANAAAAAAQ KIKDECEHDL TEAIPALEMA VQALNTLKPQ
DITLVKSMKN PPVGIKLVME AICIMKGVPA ARKPDPAGTG KMLEDYWTPS QKLLGDLKFL
DALRSFDKDN IPQNVINLIR IKYVTNPLFD PNIIRTMSSA CEGLCKWVRA MEVYDRVIKV
VGPKKESLAQ AEAELGIQME KLNEKRKVLK GVTDKLQSLN DYFMAMTRKK KGLEDNIELC
SKKLVRAEVL IGGLGGEFER WSQAAIELRE RFVNVTGDVL LASGVIAYLG AFSVEFRNEL
VRGWQRECLS QDIKCSNKFS IISVLGDPVK IRLWKIAGLP VDNFSIDNSI IVTNGRRWPL
MIDPQGQANK WVRNMEKANN LCIIKPTDSN FMRTLETSIQ FGYPVLMEEI GEELEPALDA
VLLKATFKKG QTEFIRLGEN VIEYNSSFVF YMTTRMRNPH YLPETTVKVV ILNFMITPLG
LEDQLLGIVA AQEKPELEEK KNLLILESAA NKQLLKEIED KILKVLSSEG NILEDETAIN
VLSSSKVLSE EIFAKEAVAA KTEIEIDETR NGYRPVAMHS SILFFCISEL ANIDPMYQYS
LNWFIGMYLM SIANSKPSIH LAKRIINLNE NFTKSIYKNV CRSLFEKDKL LFSTILCIGL
LKGRSEIHEE TWQFLLTGGI SFEMKIPNPA PSWLTSKSWS EIIRASNLPG LPGLYLRMDV
QQNINQWKVL YDSPVPHEVD YPEPWNNVQD LDRLLVLRCF RPDKLIPAFQ MYISKKIGQE
YIEPPGFDLP ASYSESNCYT PLIFILSKGS DPNAALFKFG EERGYDASRI ETISLGQGQG
PVAAAMIERG IIDGSWVVLQ NCHLAASWMP QLEKFCSDVI VPDKVNASFR IWCTSYPRIK
MTNEPPKGLR NNLLRSYITD PISDPTFFEG CTKKHPWQKL LFGLCLFHAL IQERRNFGPL
GWNIPYEFNE SDLRICMQQL QMFLNDYDDI PLTALKYLAG ECNYGGRVTD DKDRRLIGSL
LDVFYNIKII EDDNYKLSAS GIYYAPKSGN HDVFVEYIRS LPLISRPEVF GLHENADITK
DNQETSQLFD SILLTQPRQS VVGAGGTGGM VISLADDMLS KIPPDFDISQ IGELYPIMYH
ESMNTVLRQE LIRFNRLTEA IRFSLQDVQK AIKGLIIMSG ELDEVFNGML LGRVPALWLR
KSYPSLKPLG GYFEDFLARL KFFQTWINKT TPTVFWISGF YFTQSFLTGV NQNYARKYKI
PIDQVGFEYQ VEEEETEKPA KPDDGAFISG LFIEGCRYDR QTHALNESYP KILYDTIPIV
WLKPGIKTNF IPAKTYACPL YKTSARRGVL ATTGHSSNYV MSVELPSKQP QSHWINRGVA
ALCQLDN
//
