ID T1IV34_STRMM Unreviewed; 1103 AA.
AC T1IV34;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=ENTH domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR005023-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR005023-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in tRNA = a pseudouridine in tRNA;
CC Xref=Rhea:RHEA:54572, Rhea:RHEA-COMP:13339, Rhea:RHEA-COMP:13934,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|ARBA:ARBA00036943};
CC -!- SIMILARITY: Belongs to the epsin family.
CC {ECO:0000256|ARBA:ARBA00010130}.
CC -!- SIMILARITY: Belongs to the pseudouridine synthase TruD family.
CC {ECO:0000256|ARBA:ARBA00007953}.
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DR EMBL; JH431572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1IV34; -.
DR STRING; 126957.T1IV34; -.
DR EnsemblMetazoa; SMAR005023-RA; SMAR005023-PA; SMAR005023.
DR eggNOG; KOG2056; Eukaryota.
DR eggNOG; KOG2339; Eukaryota.
DR HOGENOM; CLU_282906_0_0_1; -.
DR OrthoDB; 168195at2759; -.
DR PhylomeDB; T1IV34; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd16990; ENTH_Epsin; 1.
DR CDD; cd02576; PseudoU_synth_ScPUS7; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 3.30.2350.20; TruD, catalytic domain; 2.
DR HAMAP; MF_01082; TruD; 1.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001656; PsdUridine_synth_TruD.
DR InterPro; IPR011760; PsdUridine_synth_TruD_insert.
DR InterPro; IPR042214; TruD_catalytic.
DR InterPro; IPR003903; UIM_dom.
DR NCBIfam; TIGR00094; tRNA_TruD_broad; 1.
DR PANTHER; PTHR13326:SF31; PSEUDOURIDYLATE SYNTHASE 7 HOMOLOG; 1.
DR PANTHER; PTHR13326; TRNA PSEUDOURIDINE SYNTHASE D; 1.
DR Pfam; PF01417; ENTH; 1.
DR Pfam; PF01142; TruD; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00726; UIM; 2.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50984; TRUD; 1.
DR PROSITE; PS50330; UIM; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500}.
FT DOMAIN 39..170
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT DOMAIN 794..1013
FT /note="TRUD"
FT /evidence="ECO:0000259|PROSITE:PS50984"
SQ SEQUENCE 1103 AA; 124688 MW; 54BFCFA9217D8712 CRC64;
MKKILLRFLN VSLTRFLSEI IVFFNMAMNP SGIRRNLKNI VHNYSDAQVK VREATSNDPW
GPPSTLMSEI ADLTYNVVAF SEIMQMIWKR LNDHGRNWRH VYKALVLLEY LIKTGTEKVA
QQCKENIYAI QTLKDFQYIE DNKDQGMNVR EKAKQLVTLL KDDERFKNER ARALKAKERF
AQASSGISSD VLTASGGYRS DSFSTDSNVS TELECARPQT IGEEELQLQL ALAMSKEEAD
QEEQKRKSDD VRLQMAITQS QEDFSVSPKD EIHPALSFGQ MAANRSLDES RSGFKASDEE
RGSQSSLFDL LALAAPVSSN TSTITTDPWG MPFKNQTEDL DPWQPISNNN IRAASTPPVL
SDPWAPKPAR STTPLTGFGY PDSERNVDFR QTIVSPYQMS MKKTPESFLG ENSALVNLDA
LVSSKPADQC APTTNPFIQN PFHMQQQQQQ QQRPSINQLR SQQIGGSCSA AITTQATLSN
GPSGPAINNP FFWEICTSKR NLSSCIQGRR KIHSKPNGAV QGRTIDENIC DCLEPRNLVE
GDVGITERVN PLSPFVGVIK QRYSDFIVNE IDTSNCVIKL TKLDVPEGDP EVVQDAIMNL
GSDVVDKLEN LLKTPDSAEP VVIKMSNDDS KEKRTKIHST IRQNYCQLQS STEERDGVKV
IIVSHNKLGD KRKSNNWPVN QPNFLKFVMF KENRDTMDAV NTIAKALRVK TSSFSYSGVK
DKRAKTSQLV TVYRISAERL AKLNLRGMTL GNYEYVKYAL QLGDLNGNRF KIVLRKITGD
GDLEEILTNL HKNGFINYYG MQRFGTSTVP THHIGRALLL GNWKEAIELI MKPRPGENDE
LTECRKIWWE TRDAKTALSK LFKKHIIEAH LLRGLSQNNP NDYIPRNTRL MYIHSYQSFI
WNRIVSERIK KFGIHVLNGD LYFKKDDPEN SDVIKTKRNN DMPSIYNSDD NDTNIDIFDV
VMPLPGSSVI MPKNDVAQIY EEILKEENMD FSKSYSNVRA YALHGGYRKL VVLPGNMSST
IRKYDDSTIP LVFSDLEILK DSSSTTEFVE SEESTGVHTA VCIEFSLPSS SYATMALREV
NFGFCIVAHI FWLGKYDFLT RLD
//
