ID T1IZ19_STRMM Unreviewed; 1114 AA.
AC T1IZ19;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=acetylcholinesterase {ECO:0000256|ARBA:ARBA00013276};
DE EC=3.1.1.7 {ECO:0000256|ARBA:ARBA00013276};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR006488-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR006488-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- FUNCTION: Rapidly hydrolyzes choline released into the synapse.
CC {ECO:0000256|ARBA:ARBA00037263}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetylcholine + H2O = acetate + choline + H(+);
CC Xref=Rhea:RHEA:17561, ChEBI:CHEBI:15354, ChEBI:CHEBI:15355,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089; EC=3.1.1.7;
CC Evidence={ECO:0000256|ARBA:ARBA00000347};
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964}.
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DR EMBL; JH431704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1IZ19; -.
DR STRING; 126957.T1IZ19; -.
DR ESTHER; strmm-t1iz19; ACHE.
DR EnsemblMetazoa; SMAR006488-RA; SMAR006488-PA; SMAR006488.
DR eggNOG; KOG1426; Eukaryota.
DR eggNOG; KOG4389; Eukaryota.
DR HOGENOM; CLU_281362_0_0_1; -.
DR OrthoDB; 5475808at2759; -.
DR PhylomeDB; T1IZ19; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0003990; F:acetylcholinesterase activity; IEA:UniProtKB-EC.
DR CDD; cd18498; BACK_RCBTB1_2; 1.
DR CDD; cd18298; BTB_POZ_RCBTB1_2; 1.
DR CDD; cd00312; Esterase_lipase; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR InterPro; IPR000997; Cholinesterase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR43918; ACETYLCHOLINESTERASE; 1.
DR PANTHER; PTHR43918:SF12; ACETYLCHOLINESTERASE 1; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00135; COesterase; 1.
DR Pfam; PF00415; RCC1; 5.
DR PRINTS; PR00878; CHOLNESTRASE.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
DR PROSITE; PS50012; RCC1_3; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Neurotransmitter degradation {ECO:0000256|ARBA:ARBA00022867};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487}.
FT REPEAT 112..164
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 165..217
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 218..269
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 270..320
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 388..455
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT ACT_SITE 819
FT /note="Acyl-ester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
FT ACT_SITE 946
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
FT ACT_SITE 1060
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
SQ SEQUENCE 1114 AA; 124801 MW; B698647D4FD37DA6 CRC64;
MLSCVRDSTF QVRYDSKTKM DLEKWPIFSL LKPCFISTIR IACVFGSSGN EALVITVDDD
VFALGSNCSS CLGLGDSHGR LEPFKVEALC RKFIKGVAYG SGPHCLAYNE FGELYSWGHN
GYGQLGNGTT NQVLVPNLVT INLIGKKIVE VSCGSHHSLA RTSDGELYAW GQNNCGQVGS
GTTTNQSTPR KVTAGINGKN VVAIACGQTS SMAVLDNGEV FGWGYNGNGQ LGLGNNVNQT
NPCRVVNLQN VVITQIACGY AHTMALSDEG TVFAWGANSY GQLGTGNKAN LVVPEKIGEE
IGRVVEIACS HYNHISAAVT QMSKVYMWGQ CRGQSVVSST ETPFHSLHDV FACFASPAVT
WRPMKLDDVP ITRVTDSLKL AFNDAETSDV KFKIQGQLIH VHKAILKIRC EHFRSMFQDH
WEEDGKDTVE ISQFSFPVYN AFLQYLYTDT VDLPPEEAIG LLDLANSYCE QQLKRQCERI
IKQGITVENA AMLYAAARKY EAEDLEEFCF RFSMNHMTAI AQTEAFRKLE EQTLKTFIVK
AAQNVFEVAP KLWKPWDVRD HESIDTFMIK REISEAKDKR SAGPRRNMAA GPRRREKLSS
YRSLLLLVTI ALVNASWTEE EEDPLLVLTT KGWVRGVTLN AVTGKKVDAW LGIPYAKPPL
GYLRFRHPRP KEQWSGVWNA TKLPNTCCQV NDTYFGDFPG SMMWNPNTPV SEDCLYINVW
APRPRPSRAT VMVWIYGGGF FSGSSTLEIY DPKVLVSEEN VVVVSMQYRV ASLGFLFLDR
KDVPGNAGLF DQLLALQWVH DNIARFGGNP DNVTLFGESA GAVSVSLHLL SPLSRDLFSQ
VILQSGAATA PWSFVPYNKA RVHALRLAEA VRCPHTMREV EAMVECLRRT DPITLVENEG
SDSLGICEFP FAPVIDGSFL DETPQMSLKR KSFKKAPMMV GSNTDEGNYF LIYFLPELLP
LAENVYVDRE DFVKSVRKLH PDLNTIAQDA VVFEYTDWLN PDDPDRNRDA LDKSVGDYYF
TCNVNEFSYR YVQSGQNVYM YYFTHRSTVT PWPKWMGVLH ADEIAFLFGE PLNPAKGYTT
AEQELSRRMM RYWTNFAKTG FILLTREGLF NYQK
//
