ID T1J6H6_STRMM Unreviewed; 621 AA.
AC T1J6H6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Proline dehydrogenase {ECO:0000256|RuleBase:RU364054};
DE EC=1.5.5.2 {ECO:0000256|RuleBase:RU364054};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR009246-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR009246-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate.
CC {ECO:0000256|RuleBase:RU364054}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a
CC quinol + H(+); Xref=Rhea:RHEA:23784, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17388, ChEBI:CHEBI:24646, ChEBI:CHEBI:60039,
CC ChEBI:CHEBI:132124; EC=1.5.5.2;
CC Evidence={ECO:0000256|RuleBase:RU364054};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|RuleBase:RU364054};
CC -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC glutamate; L-glutamate from L-proline: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004739}.
CC -!- SIMILARITY: Belongs to the proline oxidase family.
CC {ECO:0000256|ARBA:ARBA00005869, ECO:0000256|RuleBase:RU364054}.
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DR EMBL; JH431878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1J6H6; -.
DR STRING; 126957.T1J6H6; -.
DR EnsemblMetazoa; SMAR009246-RA; SMAR009246-PA; SMAR009246.
DR eggNOG; KOG0186; Eukaryota.
DR HOGENOM; CLU_018202_3_1_1; -.
DR OMA; GPLKKYH; -.
DR OrthoDB; 5473051at2759; -.
DR PhylomeDB; T1J6H6; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0004657; F:proline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006562; P:proline catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.220; -; 2.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR002872; Proline_DH_dom.
DR InterPro; IPR015659; Proline_oxidase.
DR PANTHER; PTHR13914:SF0; PROLINE DEHYDROGENASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13914; PROLINE OXIDASE; 1.
DR Pfam; PF01619; Pro_dh; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|RuleBase:RU364054};
KW Flavoprotein {ECO:0000256|RuleBase:RU364054};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU364054};
KW Proline metabolism {ECO:0000256|ARBA:ARBA00023062,
KW ECO:0000256|RuleBase:RU364054};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500}.
FT DOMAIN 152..585
FT /note="Proline dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF01619"
FT REGION 53..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 71311 MW; 01D4BCEBA54BCCB9 CRC64;
MASLKCASYA LQTSKFLIPR SCQSYRFTAL TTTFRHKSNT STYIGLDSLN DAKRQSRGAN
DGQSPSEPSS FDPLDISFEN AERAYKSKST WEIARALIVF SLCSNDYLVK NNMKIMKWTR
KVLGKRLFEM VMRATVYGQF VAGEDQNTIS PTLERLRQFG VKSILDYSVE EDLSSEQAEK
VELEAYTAPT VDLKQYQPTR LFADRRRLVT SARTYFYMNE AQCEKNMEIF LKCIESVSGI
TNATGFTAIK LTALGRPQLL LQLSATIARS RKYFEEVTGL TGNIILQDIG PDVFMKRFHE
KHISTDSKDI KSWLNQMTYD QKGLIHLFSW SGLIDSNILL TDLFRVPNLN TGRMENIISS
LTEEEEEMFR NMMRRLRTIA QVATERDVRV MVDAEQSYFQ PAISRITVEL MRKYNKEKAI
IFNTYQCYLK KALQNVLLDV EQASRQGFYF GAKLVRGAYM DQERERARVI GYGDPINPTY
ESTNDMYNRT LLECLQKIKQ SGDKSISVMV ATHNEDTIRF AVTKMKELGI GPRDRVVCFG
QLYGMCDQVS FPLGQSGYSV YKYVPYGPVS EVLPYLSRRA QENQGFFTKV AKERRLLKSE
LKRRILSGQI FYKPVGYYTP V
//