ID T1J8N8_STRMM Unreviewed; 530 AA.
AC T1J8N8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR010074-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR010074-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; JH431958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1J8N8; -.
DR STRING; 126957.T1J8N8; -.
DR EnsemblMetazoa; SMAR010074-RA; SMAR010074-PA; SMAR010074.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG4641; Eukaryota.
DR HOGENOM; CLU_014808_1_0_1; -.
DR OMA; YMAKNIS; -.
DR OrthoDB; 927694at2759; -.
DR PhylomeDB; T1J8N8; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 339..475
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 530 AA; 61549 MW; 8E3C35AA43109E23 CRC64;
MPYNCLQSIT ISKNDIRTFY ELDFSFNKLT QIPKHFHEMF FMSFYDLSYN NINTVSKTDF
DILPHVMYLN LSDNNLRSLP QDTLNDLFLL NELNLSHNFI SDLPENIFDK NIFLQKLDFD
STNSLKVLRL ESNDIVEFRL DNTKPFRFEN IENHFCSSPP KLNGTSLANI QNNLLCDYAE
NCPVSCHCYI DDIENILWVL IDCTNSKLTH FPNITSYGLS VAIHLNLSHN QISSLPSKSD
PIWTKITILD LSHNRIDTLK NMTLRPILTT LYLTYNSLSE FDHHIASLSQ VTHLKLANNP
WKCNCEMSKL LYKSEIVYYM FSKGICLKFV SDDDIDADKV YDAFVSYSNE DENWIRDFLV
PGLETGNPTY NLCLHNRDWL AGEFITDQIV KSVKSSRRTI IVLTDNFLNS PWSRLEFDVA
YQQGLKDQVR RLLIVIPNEV PDLSQIDPNF KTFITLTTYI QANKPHFWSK LRASMPRTKP
KSKSSTTRRS VYLNSDVSHE ENIEMNTKYT PGALRLIHSE FGRRHKIASD
//
