ID T1J915_STRMM Unreviewed; 702 AA.
AC T1J915;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR010206-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR010206-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU361147};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU361147}.
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DR EMBL; JH431968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1J915; -.
DR STRING; 126957.T1J915; -.
DR EnsemblMetazoa; SMAR010206-RA; SMAR010206-PA; SMAR010206.
DR eggNOG; KOG1175; Eukaryota.
DR HOGENOM; CLU_000022_3_6_1; -.
DR OMA; INVSYNC; -.
DR OrthoDB; 144557at2759; -.
DR PhylomeDB; T1J915; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF244; ACETYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361147};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500}.
FT DOMAIN 33..94
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 103..517
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 572..661
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 702 AA; 78777 MW; C91624E9DA7210BD CRC64;
MASSSNGSSS ATAVYEPNAR IRKEAHITSM DQYREMYRLS IDDPDKFWGE IAKEFYFHEE
SPTKRRLVYN LNVSEGPVEI KFMAGAKLNI CYNALDRNIK EKKYAKNIAY YWVGNDPKEC
AQITYAELLI LVCKFANVLK SKGVKKGDRI AVYMPMIIEL VVTMLACARI GAVHSVVFGG
FSADSLTERL IAAQCKIIVT ADGTWRGPKL INLKEIVDDA LTKARNQNHV VETCIVVQHL
GNLSSNMNKS VSEDEKHPSK RFCHDLKTSW NTATDFWWHD LIVSADESCA PEWMDAEDDL
FMLYTSGSTG KPKGVVHSIA GYMVYAATTF KYVFDHHQGD VFWCTADIGW ITGHTYVVYG
PLLDGATSVM FEGIPFYPDA SRYWQIIEKY KVSKFYTAPT AIRALMKYGD EFVTKHNCSS
LKILGSVGEP INPEAWLWYY NVVGNKKCVI VDTFWQTETG GHVLTPIPGA TPAKPGSATF
PFFGVIPAIL SEEGKELEGP AEGYLVFKRP WPGMMRTLYG DHERFETTYF KKFPGYYCTG
DGARRDEDGY YWVTGRVDDM LNVSGHLLST AQVESCLIEH AAVSEAAVVS HPHPVKGECL
YCFVTLKEVG NFILIDSKLV HNFCNELIQA LRSIVRKKIG PFASPEYVQH APGLPKTRSG
KIMRRVLRKI ASNDRDMGDI STLADESVVE QLFSLRPKDV AV
//
