ID   T1J948_STRMM            Unreviewed;       492 AA.
AC   T1J948;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Peptidase M12B domain-containing protein {ECO:0000259|PROSITE:PS50215};
OS   Strigamia maritima (European centipede) (Geophilus maritimus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX   NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR010239-PA, ECO:0000313|Proteomes:UP000014500};
RN   [1] {ECO:0000313|Proteomes:UP000014500}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA   Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA   Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA   Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA   Muzny D.M., Gibbs R.;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:SMAR010239-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2015) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR   EMBL; AFFK01022209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1J948; -.
DR   STRING; 126957.T1J948; -.
DR   EnsemblMetazoa; SMAR010239-RA; SMAR010239-PA; SMAR010239.
DR   HOGENOM; CLU_577879_0_0_1; -.
DR   OrthoDB; 3404316at2759; -.
DR   PhylomeDB; T1J948; -.
DR   Proteomes; UP000014500; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1620.60; -; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   InterPro; IPR041645; ADAMTS_CR_2.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR   PANTHER; PTHR11905:SF243; SOL NARAE, ISOFORM C; 1.
DR   Pfam; PF17771; ADAMTS_CR_2; 1.
DR   Pfam; PF13582; Reprolysin_3; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..492
FT                   /note="Peptidase M12B domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004590315"
FT   DOMAIN          205..407
FT                   /note="Peptidase M12B"
FT                   /evidence="ECO:0000259|PROSITE:PS50215"
FT   ACT_SITE        349
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT   BINDING         348
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT   BINDING         352
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT   BINDING         358
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ   SEQUENCE   492 AA;  55068 MW;  FEC87B7E165CE07C CRC64;
     MSIGPIFVLG SLLIWNQCSP SPYSVSRENK NESAVEKLHF ILPDVEKESS IEELEVAKLP
     KTESLSFLHF SMFGESYSFK LVLANSVFSP DFKILQSQLQ DKVLKVYQPS WDGFVDDKVI
     IRNYQGQHTA TKTLKLKSQF DRTLANRGKT GLGETGFPVS PKVAPKTKLG KTGKITPLGK
     MELGETVSVK TKPNSGSSKL QHNVATIEVL IFLDEIVHDK LVENDVGIKK YLGIFWNAVH
     NKYKVFTNPK IQFSLSGAIV LNDTSWITDI FLAPNKPADE EYLENFMLHT GLDLSFIDEE
     NKINTGTLGM ANQNGICVVD ELHEEILSSC VIEDHHAPTF EGVLTAAHEF GHLLSAEHDP
     LQKCDKYGLM SPGDEDISPS TMIFCNFSIQ YITEYLNYDA SCLYDEPQPH MPIGPEVPTM
     TREEICKTAY GANFEAVPME FYTNSINYTD PCVYIICVES NDSNNLQNLK WVPEETPCDD
     EKVCIKGVCT TK
//