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Database: UniProt
Entry: T1JE16_STRMM
LinkDB: T1JE16_STRMM
Original site: T1JE16_STRMM 
ID   T1JE16_STRMM            Unreviewed;      1431 AA.
AC   T1JE16;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   05-JUN-2019, entry version 34.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
OS   Strigamia maritima (European centipede) (Geophilus maritimus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX   NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR012052-PA};
RN   [1] {ECO:0000313|EnsemblMetazoa:SMAR012052-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; JH432114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 126957.SMAR012052-PA; -.
DR   EnsemblMetazoa; SMAR012052-RA; SMAR012052-PA; SMAR012052.
DR   OMA; WDEDEAP; -.
DR   OrthoDB; 20210at2759; -.
DR   PhylomeDB; T1JE16; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       93    180       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   REGION      241    297       Disordered. {ECO:0000256|MobiDB-lite:
FT                                T1JE16}.
FT   REGION      345    370       Disordered. {ECO:0000256|MobiDB-lite:
FT                                T1JE16}.
FT   COILED      507    527       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    241    263       Polar. {ECO:0000256|MobiDB-lite:T1JE16}.
FT   COMPBIAS    264    297       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                T1JE16}.
SQ   SEQUENCE   1431 AA;  163383 MW;  7B5263C89E202823 CRC64;
     MTSESWKMST TGGYPTCDNM PSISPVHELV EPGSKDYCPN VDLMNWNNAT SKYPSETEYK
     TLQLGGFVNH LLGTTSEAVI PSELENATTD YQVECSYPTG TNPNSWENNH PRNWSCNQVI
     EWLYYSVFVR DYENAQIDNF RGISGKDLVQ LKKSDFIQLL RSENYADRAF TQLQQHLYQY
     DYNSTNIQNV INNMSITNSY DTNNATYPYI TDMYTELEQP RTYNTNLCQY DNSDVWYNTS
     RSDVESDGEC NRSPYTGSPY PDITSKHTDD DPRRPPKRGP GRPAGRESKK KKTGQRSSRL
     WEFIRDLLKD KDTCPRLVKT YYSNHILEPV PKTGRFPKKL LHQRTMSQNR RAVGTSGPAP
     KRFKAHDEEK ESGFEKELAK FVVDDDEMVS ADKNDFDPQE NIGEGPEYIS TTEKWARPPV
     PRMDSSKDKL IFQQIEIDHY IGKPISGMPG SQIGPVPVIR MYGITADSNS VMCHVHGFVP
     YFFVPAPLNF VDADCRKFKN ALNAVILKDL RSNKENVQET VLAVELMQRE NIYGYTGKTK
     ITFLKLTMAL PRLIAPAKRL LGAGIDIPGY GNRAFDSFES NIDFEIRFMV DSNVVGCSWI
     ELLPNKYKIR KNSLMSRCQI EVDVSIDDFI AHLPEGEWEK VAPFRILSFD IECAGRKGIF
     PEPKKDPVIQ IANMVQRQGD KDPFIRNVFT LDTCAPIIGS QVLSYNRESE MLNKWADFVR
     EVDPDIITGY NIQNFDLYYL INRANHLKSQ NFSYLGRVKD IQTVVRSVML QSKQLGKREN
     KSINIEGRTQ FDLFLVLLRD YKLRSYTLNA VSYHFLQEQK EDVQHSIITS LQQGTDKTRR
     RLAVYCLKDA YLPLRLLDKL MCFFNYMEMA RVTGVPLSYL LTRGQQIKVM SQLLRKAKEY
     GFIIPAMEIE TGDEFTGATV IEPIAGYYDV PIATLDFASL YPSIMIAHNL CYTTVLTSPS
     EREKLSADDF IKTPSNAYFV KKNMRKGLLP EIVENLLSAR KKAKDDLKKE TDPLRRKVLD
     GRQLALKMSA NSVYGFTGAQ VGKLPCLEIS GSVTAFGRQM IEKTKNLVEE KYSIVNGFKY
     DAKVIYGDTD SVMVKFGFDN LTETMQLGRE AALYVTESFI SPIKLDFEKV YFPYLLISKK
     RYAGLYFTRP EIHDKMDCKG IETVRRDNCP LVANLMNTCL EKLLIERDRE GAIEYAKQII
     SDLLCNRIDI SQLVITKELT KTDGDYKAKQ AHVELAHRMK KRDAGSAPNL GDRVPFVITA
     APKGTAAYLK SEDPIYVLEN NVPIDTGYYL ENQLSKPLLR IFEPILGSKA ESILLRGDHT
     RTKTVAISRA GLMAKFTTKR ESCIGCKVAL DSGRICNHCK PRESEIFQRE IENLDALEEK
     FSRLWTQCQN CQGSLLEDVL CTSRDCPIFY MRVKVQKDLV AQDKLIQSLS F
//
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