ID T1JHR6_STRMM Unreviewed; 788 AA.
AC T1JHR6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Limulus clotting factor C {ECO:0008006|Google:ProtNLM};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR013397-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR013397-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; JH431872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1JHR6; -.
DR STRING; 126957.T1JHR6; -.
DR EnsemblMetazoa; SMAR013397-RA; SMAR013397-PA; SMAR013397.
DR eggNOG; KOG3627; Eukaryota.
DR eggNOG; KOG4297; Eukaryota.
DR HOGENOM; CLU_356157_0_0_1; -.
DR OMA; MICAGNE; -.
DR OrthoDB; 3060164at2759; -.
DR PhylomeDB; T1JHR6; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 5.
DR CDD; cd00055; EGF_Lam; 1.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF7; HYALIN; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF00084; Sushi; 5.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00032; CCP; 5.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 4.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50923; SUSHI; 5.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..788
FT /note="Limulus clotting factor C"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004590577"
FT DOMAIN 124..151
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 154..214
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 224..280
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 282..344
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 347..410
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 456..517
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 530..788
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DISULFID 141..150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 156..199
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 185..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 251..278
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 315..342
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 381..408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 788 AA; 86230 MW; 4FB80C766E227047 CRC64;
MPYKTGNEKV SFRSVYMTGF QLSLFLLLSL TPSFDAGPVD LGLCQPRLLA CQCGQGNSYP
IYMQIPQCTK FYRWKPNCAD CKDVPSDSEL CAVFSNCLDC EPDIKQCLRC PAGRYGTWCT
GVCSVCANGG ICNRDTGRCD CPEGFTGIQC EETKGCLAPH SHIIGGEVID WTQQYLPGAA
VTYKCNEGFE MQGIPTLYCL ENGFWNLHPP TCIPSAISTS PPTIDCERQN EDILHGSVNH
DPQSKMLTYS CINGYELIGD ALRICAPDGN WTGTEPECVK IITCDLPPIP ASTHFTVSTQ
SRTNLAIGTR VDLSCQPDFV LLGDDSIVCR VDGTWSASPP NCVHQDHTCT HPGNFVNGEI
RVAGDRSSSA FIIGATIHFT CHPLNYLSGD SSITCNINNT WSGTVPTCIK VITCPPIETI
HSGHVNIFAP STDSSSTFQV SGNSSVTSRI GFVPRFRGGL PTQSTRALTV QLPKGHHHIG
TRASFSCISR YYDLVGSKLR SCMPTGEWSG RPAACIPECG RSSGPRIPLI THGTPSVMGQ
WPWQVGIARR LEEDNPLGDW FIMCGGSVIS ESLVLTAAHC VTHSGTNVMV PNDEFRLYFG
KYFRNDSRDD EQVQVRSVSE IHVHPDFEPS TFESDIALIR VEPEITFTSR VQPVCLPSEN
DGDDRLAEGR QGTVIGWGMK EDSTYSDILQ HVQVPVVPGQ QCQKDYRKIG VPIVVSSNMI
CAGNETGGFD SCNGDSGGPF VFPTHSQSDR WVLEGIVSWG SPFGCGNERQ YGGYARVRRF
TNWIEHFI
//
