ID   T1JKU7_STRMM            Unreviewed;       545 AA.
AC   T1JKU7;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE   AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
OS   Strigamia maritima (European centipede) (Geophilus maritimus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX   NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR014477-PA, ECO:0000313|Proteomes:UP000014500};
RN   [1] {ECO:0000313|Proteomes:UP000014500}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA   Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA   Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA   Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA   Muzny D.M., Gibbs R.;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:SMAR014477-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2015) to UniProtKB.
CC   -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC       inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC       {ECO:0000256|RuleBase:RU368069}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC       ECO:0000256|RuleBase:RU368069}.
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DR   EMBL; JH431868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1JKU7; -.
DR   STRING; 126957.T1JKU7; -.
DR   EnsemblMetazoa; SMAR014477-RA; SMAR014477-PA; SMAR014477.
DR   eggNOG; KOG3830; Eukaryota.
DR   HOGENOM; CLU_014030_1_0_1; -.
DR   OMA; CNLAFRY; -.
DR   OrthoDB; 8983at2759; -.
DR   PhylomeDB; T1JKU7; -.
DR   Proteomes; UP000014500; Unassembled WGS sequence.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR   PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Lysosome {ECO:0000256|RuleBase:RU368069};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW   Signal {ECO:0000256|RuleBase:RU368069}.
SQ   SEQUENCE   545 AA;  62223 MW;  EBAAA99F0745ECFC CRC64;
     MKETDPVNVI LVKHGSKGDR LLFRYPFSEI TRESKKQTTS VARIKPYALV SSFAEDNARQ
     PPLSNISNGQ LVGFSDKVLS NLFAVTTQLS RQKFELKVND VRFVGHPTLL QSAQVSPKRL
     TSTLILFHIV FALPANASYS VVRCYHDLSY RLGVCLRHEE RRCGHLSKET KIMLAAHDEV
     SGQTDVKESV FDMILNRSQL AKDLKYIYDE LCSSGVIQMR INRWLQISFC LPQRIHSFSS
     PDFVLDPESL DRCINSLKPY HALLLLVSEC DFVSSLPLGA SPALIRIIQA SSPLKSLQEL
     AIDADLSITQ VFRVVGHLIY WAKATIIYPL CETNVYILSP NAPTHIDSPL VEKFNEIFPG
     INLLVIMAEF SLPVSLSQRG NPTHIAYQQT QLLQIIIWML QHNLLMQLHT YVYLIPTEEC
     VLSRPPSRGS SSSEWSRNRL DLTIDIDDTS WSNFPACVSS LSSPVANNSQ SNLRLHNENS
     DDIRLFDRLR RYFCGKYHLE EIMYYENIRR TPLLFLLDKF RDILITCEHE DDAVSMFYKQ
     SKTWS
//