ID T1JLR4_STRMM Unreviewed; 456 AA.
AC T1JLR4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=phosphatidylinositol N-acetylglucosaminyltransferase {ECO:0000256|ARBA:ARBA00012420};
DE EC=2.4.1.198 {ECO:0000256|ARBA:ARBA00012420};
DE AltName: Full=GlcNAc-PI synthesis protein {ECO:0000256|ARBA:ARBA00032160};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR014794-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR014794-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
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DR EMBL; JH431663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1JLR4; -.
DR STRING; 126957.T1JLR4; -.
DR EnsemblMetazoa; SMAR014794-RA; SMAR014794-PA; SMAR014794.
DR eggNOG; KOG1111; Eukaryota.
DR HOGENOM; CLU_009583_19_0_1; -.
DR OMA; QCVLPTM; -.
DR OrthoDB; 24420at2759; -.
DR PhylomeDB; T1JLR4; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; IEA:InterPro.
DR GO; GO:0017176; F:phosphatidylinositol N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03796; GT4_PIG-A-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR039507; PIG-A/GPI3.
DR InterPro; IPR013234; PIGA_GPI_anchor_biosynthesis.
DR PANTHER; PTHR45871; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN; 1.
DR PANTHER; PTHR45871:SF1; PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR Pfam; PF08288; PIGA; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 52..141
FT /note="PIGA GPI anchor biosynthesis"
FT /evidence="ECO:0000259|Pfam:PF08288"
FT DOMAIN 204..330
FT /note="Glycosyl transferase family 1"
FT /evidence="ECO:0000259|Pfam:PF00534"
SQ SEQUENCE 456 AA; 51680 MW; E7720C3397CF98E4 CRC64;
MDPNNGFCPA MKHNICMVSD FFYPNTGGVE SHIFQLSQCL IKKGHKVIVI THAYGNRKGI
RYMTRGLKVY YLPFQPFYNQ CIFPTLFLTG PLMRTILIRE EITIVHGHSA FSVMANEAMI
HANNLNLKTV FTDHSLFGFA DSSAIITNKL LELVLLHVDS VICVSHVGKE NTVLRAKLHQ
DSVYVIPNAV DSSMFEPKDE VKPEKKIKNV NLSQEITIIV LSRLVYRKGT DLLVELIPKI
CEKYPKLNFI IGGNGPKRIA LEEMVERHEL YQNVTLLGAV RHQDVRRVLN KGQIFLNTSL
TEAYCMAIVE AACCGLQVVT TDVGGIPEVL PSSWNEEPGR LAWLAKPNVD DLMCVLEEAI
FDFERGRVVS SREAHNWVED VYNWENVTCL TQTVYDGVIF KRSCTLAERL RICLNGTLGR
KVFAFLVAID YLVLKVAEYF LPEKNIDRAF NFQSDL
//
