ID T1JX07_TETUR Unreviewed; 872 AA.
AC T1JX07;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=RING-type E3 ubiquitin transferase BRCA1 {ECO:0000256|ARBA:ARBA00031556};
GN Name=107371593 {ECO:0000313|EnsemblMetazoa:tetur02g10210.1};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur02g10210.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur02g10210.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CAEY01000822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015795209.1; XM_015939723.1.
DR AlphaFoldDB; T1JX07; -.
DR STRING; 32264.T1JX07; -.
DR EnsemblMetazoa; tetur02g10210.1; tetur02g10210.1; tetur02g10210.
DR GeneID; 107371593; -.
DR KEGG; tut:107371593; -.
DR eggNOG; KOG4362; Eukaryota.
DR HOGENOM; CLU_329383_0_0_1; -.
DR OMA; YITETHG; -.
DR OrthoDB; 2478587at2759; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd17734; BRCT_Bard1_rpt1; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF16770; RTT107_BRCT_5; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 31..68
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 662..758
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 172..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..648
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 99000 MW; E14DC3E5977A3914 CRC64;
MNGPVTSANK LKWDPSITNP LFIEMVDLLR CHQCKKLNYS VHNLSKCAHV LCGDCKNGIA
ARKCPLCKIP TVEIKRDSDY ESLVKDIRLL NTQYLKISFA ADKNPNKAPN NDKKIMSSPR
PVMKAVISPV KKVDNAAKGV ESSQDLSQLT EASVFTQDLS IDEDKLDDAS DTEAIGSVNK
RKGREKVQEK VIPMKKQRLA SDSTEKQSND DKNKRKDKDP VKEREAEKEK ERLKEKEKEK
EKEREKEREK EKEKEKERLK EKEKEKLREK EKEKEKLKEK ELQKKLEKEK KEAEKLEKEK
AKELEKERKE KEKELAKERA KERAKEKAKE RALEKAKEKA RLKELEEKEK AEEEKNKNKN
EDDADADAED NDKAKSKSRK KVLAKDKVKE TESDAQADNS KSSKVESSTK KRGKTVEEEV
SESKDNKVSI RGRAKKKVVE EKEKEDKNKE SESDDKRSTR SSPSKNLSSK NKDESPRRTG
RTPKNSGKPE DDKKSSEDRI DTTNDDIEEN RNKKQDLRKS VTFSPAKEFE STVSPRKSPR
SNKGNMMYSR RPITYDELPL MNSKARSETK SKEAVSETET PKSTSNSKAA SSKGRAKQKA
KEPEASVDDE DVFVKPKATS KRAARLDSTD TSPVKRQRKA KETSDESDSP SPARSTSSRS
NASKNSKSNS RILIASTLLT ADQKKTLEKL QKSLGVRITA DFPSNVTHLV TKSDSNKRAV
RSLKYMKALL SHKWIVSFDW ITESLKAGEL LPEEPYELRG TTKQPENTLG APKISRTSKK
KLLIGINFYF DGKFKAADLP NLEELKDIVS TGGGTIFDNN LRLNSALRKN ERVIIVKDKV
KDDDKSTGSA KHIETADLLA VVTAYKTDDF FN
//
