ID T1JXN3_TETUR Unreviewed; 1378 AA.
AC T1JXN3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:tetur02g12640.1};
GN Name=107371185 {ECO:0000313|EnsemblMetazoa:tetur02g12640.1};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur02g12640.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur02g12640.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; CAEY01000832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015794686.1; XM_015939200.1.
DR STRING; 32264.T1JXN3; -.
DR EnsemblMetazoa; tetur02g12640.1; tetur02g12640.1; tetur02g12640.
DR GeneID; 107371185; -.
DR KEGG; tut:107371185; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002744_2_1_1; -.
DR OMA; KNTHRED; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104}.
FT DOMAIN 263..481
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 535..654
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 702..840
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 881..1120
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 300..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1230
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1285
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1319..1367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1378 AA; 157655 MW; 2C735D340E33AAD1 CRC64;
MGHHCHHSHL LCQINYDFED DANKFKWNNL FVNSLKEILF SVHPELDAAD EALYFIESLI
FKLLRLLISN SPRNVQELEE NVLKLFPSPI EKWATSKAQN VLQECYDVQC NSNSTSSSST
ISGGKKKKLL LVNIPNNNNN SINNNRDPLG NCPLKTKHSI EKMHDLLSKE VFPYRIEMPL
TIYLCSLVEY IAADVLKLAG NYVKNIRHSF INAQDVKIAI NADKVLIDLL YGEEDDYESK
EMSNLGIIWE ESTEDGTDDE GISYDIVAKE LIHEEKQFLR DLNLIIKVFR EPFIKLLQNS
PSSLPNTPTS PTSQEDKPLI SEKDIDDIFS NIIDIYEFSV NFLGLVEDAM EMNGGDNSET
IGIGMCFEEM AENVEFEVFE KYTLDMLRQD ESSPETVPKA RLVTLLKQQP IINVLDTAGH
KFILSAKYIL PKLLLCPVIH CIHYFDYMKL LMSLATTEAD KESFKQTEGC LTPMQKQINE
ATRNRNLKIY EGYLRLNRSN QRSKNKRNML NKKILELKRC IDGFDFSSLG YDCNEFIIDG
YLQKVRKNER KTLGRHESKL FFSERFCFLF DSVLLACKPI AKENQDSVQR YRLKEKFFIC
KIEIVESDLD QCAFEIVSSA KSHNFDSNRG SIIFLAKSME EKDIWVSNLL LLSRKTILER
TLDSILAEED KKNPLRLPSP KDYIFAEKDT DNNIIFETSC NNKMSIKGAT LNKLIERLTY
HQPTDTMFGK TFLTTYRSFC SPQQLLSLLI QRFDIPLDVM DREGWSRNEV KKFKKEYLEP
VQFRVINVIK QWIDAHFYDF ERDDQLLESL RIFLKEKVSK EKSNVVKWVQ TLSNMISRKQ
QKQSNKNSEN KILSEVPPPI EYLPPNGKEN CDFELSIMTI HPLEFARQLT LYEFDLYCAV
QPSELIGLKW IKEGKEINSA NLLKISRHSN NFTYWLEREI VETVNFEERV ALMSRIIDIM
QVLSDLNNFS GIIEIMSALE SAHVHRLEHT LNALHPKHKK LIDEMRDLST DHYKKYCERL
RSINPPCVPF FGLYQTQILH FEEGNSDYID EKKGLINFSK RRKIAEITAE IQGYQNQPYC
LLVCPEIREF LESLNPIEEG KSEKDFNDYL YEQSLLIEPR GSKQPTKGAK RWPRIQNLKS
PGIKPSSVSQ NAPHPTSLPT STFMANHPQS TSSSNPTSPT LISPKTPPST TSDTSVFANV
IIGNLPTPAP TPPPIISAST ITPPPIPPRT RNFHQRTNSE SSVTSATVSP TTTTPLTPFS
FNFALANPPP PPPPPPPPPR VPRPNTILQP QSQPHLSSNS LSSPSSDHQA PPPLPPRGIT
SSLSSSNFGR TTLPRRNSTD TQPHDNVSNP FHRRNSSSSS THPHAQPQLP PKTYRAKR
//
