ID T1K437_TETUR Unreviewed; 1323 AA.
AC T1K437;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN Name=107360306 {ECO:0000313|EnsemblMetazoa:tetur05g01210.1};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur05g01210.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur05g01210.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; CAEY01001565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015782415.1; XM_015926929.1.
DR EnsemblMetazoa; tetur05g01210.1; tetur05g01210.1; tetur05g01210.
DR GeneID; 107360306; -.
DR eggNOG; KOG1933; Eukaryota.
DR HOGENOM; CLU_002359_0_0_1; -.
DR OMA; NIFIMVH; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1323
FT /note="SSD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004591208"
FT TRANSMEM 306..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..816
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 867..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1129..1146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1153..1172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1178..1199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1220..1242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1254..1277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 651..816
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1294..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1294..1308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1323 AA; 147993 MW; DA39D410A887D94F CRC64;
MDSKITITSI LVTLILKIVT GESSLTQPTT SPLQAQALPS SPEAKCVLGG ICGHGGTFQS
PIPCYEPHTP QPIANETYRA TLKELCPNLF LNNDNPPVCC SLEQIDALEK SYEAPNQFLG
RCPSCFYNWK QIFCEMTCSS RQSQFINITK VVPLESSPEK LQVQNTTYFM SETFAKGLHQ
SCKSVQTPLN LPALTIMCGI TDDGECTYRK WLNFMGLSHR SGGHSPVQIN FTFTQETQIT
TNDGLKFYPM SAQPIPCHKS IGLGFDPCSC SDCEQTCAID VLPRSARKLP PPPEPFTFFG
HPAAAIIGYL LFALIFSTSS VYFINLFLKK NKSLSHDFIG PIAAATPPAS PSREVASISS
DGKSTEEKLS LGLQFELFFE KWFTRWGIYV ADHPIPIMVI SLVASIILAC GLATIKVTTD
PVDLWVSAGS QARQDMEYFQ SNFFKFHRIE QIIATPTDNS YFRANYTSNG KVKSDRFGPA
FRRQFLKDVL ALQKEIENMQ VTNGDHTVSL KDVCYKPLGS TCATQSVFTY FHDDPNEIDD
ENYLHKVVSC PSNPTILSDD KFLCMKNGSI PLIYPEATLG GFNNNTYREA QALIIIFPIL
NFPDPKQNSD AIAWEQGFLD LVKNYSNPNV KIAFKAEKSI EDEIDRQSQS DVVTIGVSYL
IMFVYILLAL GENSNINTLL IDARFTLGFV GVLIVLLSVM SSLGFFFYLG IPATLIIVEV
IPFLVLAVGV DNIFILVQTF QRDERRPDET INQQIGRVVG EIAPSMLLSS LSMSSCFFIG
ALTPMPAVRI FALYAAVALV INFILQMTCF LSIFVLDTRR QASNRLDVFC CIKTKKSTKS
SNLNNGMLYG FFRDIYSPFL LKDVTRFIVL IIFGGWFCAS IVSLDQIHIG LEQEVSMPDD
SYMMDYFAFY KSYFQVGPPV YFMITDGYNY SDPVAQNRLC GESTCDKDSV LKILNYFSTK
TSESYLASRP SFWLSDYNQY LRSDTCCKKY ENGSQCLTNE LECETCLDDM RIRPMGKEFD
QYLPFFLNQN PGEECLSGGK ALFSGSVKLV KDSKGDLRAG PTFLMAYRKS LKTSKDFYES
LRISRQIADK LTKKLQKSGL TKATVRTYSF TDVFYEQYLT MWSDTARSLS LSIGAVFIVT
YLFFGLDFYS ASIVAFTIIM IIVNLMGMMH WWDISLNAIS LVNLVVGVGI SVEFCSHLVR
TYTISPAATR MQRAHEALST MGSSILSGIT LTDCGILVLA FAKSKIFQIF YFRMYLGIIL
LGTLHSLIFL PVLLSIIGPP LNEQRLTLMA NKSKSSSSFQ VASELSSSKY RENDSKKEQN
EKC
//
