ID   T1K440_TETUR            Unreviewed;       553 AA.
AC   T1K440;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
OS   Tetranychus urticae (Two-spotted spider mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC   Tetranychoidea; Tetranychidae; Tetranychus.
OX   NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur05g01240.1, ECO:0000313|Proteomes:UP000015104};
RN   [1] {ECO:0000313|Proteomes:UP000015104}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA   Rombauts S.;
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:tetur05g01240.1}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361114};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361114}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the tweety family.
CC       {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
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DR   EMBL; CAEY01001565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1K440; -.
DR   STRING; 32264.T1K440; -.
DR   EnsemblMetazoa; tetur05g01240.1; tetur05g01240.1; tetur05g01240.
DR   eggNOG; KOG4433; Eukaryota.
DR   HOGENOM; CLU_023758_3_0_1; -.
DR   OMA; YSPSIWV; -.
DR   Proteomes; UP000015104; Unassembled WGS sequence.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424:SF8; PROTEIN TWEETY; 1.
DR   PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|RuleBase:RU361114};
KW   Chloride channel {ECO:0000256|RuleBase:RU361114};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|RuleBase:RU361114};
KW   Ion transport {ECO:0000256|RuleBase:RU361114};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT   TRANSMEM        55..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        230..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        258..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        413..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   REGION          460..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..497
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        515..534
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   553 AA;  62287 MW;  E441130884BCF169 CRC64;
     MDLIDQFINS SIASPGGDFK MSLVAKYFHQ VPHKDIHFNW VNATFDLNDN QYQEALGIIV
     AIPGFWLILT LLFFLIFFLC RCCDVNSKKK KKLTCCKCFL FLFTILSIGV ITVGLYGNYV
     THEGMIKVQN STSKIAQDID DMNKLAAIVD KTFEKDIHDN LNLALNRVTG PIMKNYTLVN
     FIHAKIEEMK RNTNSASSII TEMRGKIFNK ANFDQIENLN VPEKEMIRTL ATWAVLISLL
     FIGLILICGV CRHSRCMLIL FSVLGLLSLV ICWVLTSVYI GFCVAVSDFC MDPEPFIYKY
     LPRESFLLDY YIKCGTIDQK SRITDNIYEK QSTDILMNLD KIALNHDEIK SHCRSNCSDL
     MFKQHMSHIV NGMNFVRAQL NKFGQYSNCQ RIHESYKHSM NHSCKDVLEG VSLMLASSSV
     TGLIFTLLVL CASHTWINIR IKRNKAMAGD ASEETAPFLA PASASSTVSS STGNLKRTRD
     NYAAASGPSS RPRYSHTPPQ TPHFVPGPNY MANAPPLGPQ STNVGQQGLQ GHQMQHHHGH
     QPLGQPHYVV NYQ
//