ID T1K684_TETUR Unreviewed; 1042 AA.
AC T1K684;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN Name=107360633 {ECO:0000313|EnsemblMetazoa:tetur05g08980.1};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur05g08980.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur05g08980.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. S6 kinase subfamily.
CC {ECO:0000256|ARBA:ARBA00009804}.
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DR EMBL; CAEY01001593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015782813.1; XM_015927327.1.
DR AlphaFoldDB; T1K684; -.
DR STRING; 32264.T1K684; -.
DR EnsemblMetazoa; tetur05g08980.1; tetur05g08980.1; tetur05g08980.
DR GeneID; 107360633; -.
DR KEGG; tut:107360633; -.
DR eggNOG; KOG0603; Eukaryota.
DR HOGENOM; CLU_000288_58_0_1; -.
DR OMA; HQAHKEG; -.
DR OrthoDB; 5489497at2759; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016239; Ribosomal_S6_kinase_II.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24351:SF175; CHROMOSOMAL SERINE_THREONINE-PROTEIN KINASE JIL-1; 1.
DR PANTHER; PTHR24351; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR Pfam; PF00069; Pkinase; 3.
DR Pfam; PF00433; Pkinase_C; 1.
DR PIRSF; PIRSF000606; Ribsml_S6_kin_2; 3.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000606-
KW 51}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000606-51};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..278
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 279..349
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT DOMAIN 616..934
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 373..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..457
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 136
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
FT ACT_SITE 732
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
FT BINDING 14..22
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51"
FT BINDING 40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 622..630
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51"
FT BINDING 645
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1042 AA; 116566 MW; 996A24E94F53A526 CRC64;
MPVDIDDFEI LKVLGTGAYG KVFLVRKLCG PDINHLYAMK TLKKSSLVNK PKTLEHTLIE
RKVLEIVRSG PFLATLHYAF QTSDRLHLVM DYISGGEMFT HLYQRDRFTE DAVRIYIAEI
VLAIEHLHKH NIVYRDIKLE NVLLDKDGHI VLTDFGLSKM FKENSENNRT HSFCGTIEYM
APEVVRHGSG GHEFAVDWWS VGVLTYELLT GASPFTLEGC PNVQAEITAR IIHDRPPIPE
YMSNVAVDFI LKLLAKDPRR RLGAGRYGAS EIKRHPFFGN LNWTHLAEKR VRAPFVPKIN
GDTDTSNFSD EFTSMSLVET PDISPPEEVP ENSFNGYEYI SPDLIAANRF YYGEAAVPIE
EVQNQEVIEY VNSEQSEDEE EIQEEDEESV QNSYASSEEE GETVDESSEE EQESEDNNDD
NSDDSEEDED EEEEEEEEED EEDDEEEEDE EENVSTIDED SISTIGEESS VTEEVEENTL
DNLAHRLNQP LLDASTIPVP EESFESSTSS TQRDINEIFG SSMSSNGSII GSINSHHNLS
PKRSVSGSSF DIDVQLHHSN YIMTSTPANP KRKFTRKTDN QHHPISPPSP ISPSPKNVLY
TLRITANSVF HQKYSLTLNS VLGDGTYSIC TKCVDRKTGE EFAVKIVHKQ SDITSEVESL
NMCQGHPNIV NLVEVLTDDY YTYIVQELLR GGELLAKVGS NGAFSEVEAS RLFRGLVSAL
NYMHTNQVVH RDIKPENLIF TDDSPDAELK IIDFGFACKI SRNEVLKSPC CTFVYAAPEV
LKIAKKLSAN ESRTYPTSSF TSSSDRYSSS SPPSTPPALS QSIQEQLANI PFVVNRSPDS
DRSYHREDGY TESCDLWSLG AVLFTMLGGN PPFAHVHDLS ASDVLEGIKN GAFDMNGPNW
AKVSTAAKSL ISGLLDVNPA ARLKLSYLTC HPWVQGHFNE SSMNISYRRT PSTPPGTYLR
QGSPGSTPVP TVGSLRLADV SEAILAKRRA CKRLFIDNNG NDCSPHIESS HKRIKTVLTR
EYNSLNNNLF LFKAHPLLST KN
//
