ID T1K8L4_TETUR Unreviewed; 542 AA.
AC T1K8L4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Beta-hexosaminidase {ECO:0000256|PIRNR:PIRNR001093};
DE EC=3.2.1.52 {ECO:0000256|PIRNR:PIRNR001093};
GN Name=107361750 {ECO:0000313|EnsemblMetazoa:tetur07g01750.1};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur07g01750.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur07g01750.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231,
CC ECO:0000256|PIRNR:PIRNR001093};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285, ECO:0000256|PIRNR:PIRNR001093}.
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DR EMBL; CAEY01001877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015784113.1; XM_015928627.1.
DR AlphaFoldDB; T1K8L4; -.
DR STRING; 32264.T1K8L4; -.
DR EnsemblMetazoa; tetur07g01750.1; tetur07g01750.1; tetur07g01750.
DR GeneID; 107361750; -.
DR KEGG; tut:107361750; -.
DR eggNOG; KOG2499; Eukaryota.
DR HOGENOM; CLU_007082_0_3_1; -.
DR OMA; VVEVWPM; -.
DR OrthoDB; 178991at2759; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06562; GH20_HexA_HexB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001093-2};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001093};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001093};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..542
FT /note="Beta-hexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004581151"
FT DOMAIN 26..161
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 182..500
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 338
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
FT DISULFID 58..117
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-2"
FT DISULFID 291..343
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-2"
FT DISULFID 518..536
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-2"
SQ SEQUENCE 542 AA; 61346 MW; 2A442EA5CF04D6D0 CRC64;
MFSQLLLPLT IFCVSIGLQR VNCANLWPQP QILNQDATFY TLDPSSFKLI LAKERVGCEI
LEKAIERYSK LLFLSDCSRL NTDCDGKKLP TEPVEDITND PNYGGQLFNL SIDTNSCEKF
ITSESFEIYT LRVRTADYPE DAALFAPFWG ILRGLETFSQ LVTRYKGNWI INSTFIVDYP
RFTFRGVLLD TSRHYIPVHL LLQNLDAMAY NKMNVFHWHI VDDQSFPFVS STFPKLSAAG
AFRPTHIYTP EDVSTVLEYA RVRGIRVIAE FDTPGHTLAW GKGIPGLLTQ CYKAGKPVKG
SYGPIDPSQN STYTFLKSLF AEIAKTFPDD FVHLGGDEVD FSCWQSNPDI NSFMESQGIT
GDYAALESFY LQKLVNIMDT LKKNYIVWQE VFDNGVKLRS DAVVHVWKSG DYQSELSKVV
AGGYRTILSS PWYLNYISYG SDWQTYYKVE PLHFNVTSHG EYDLVIGGEA CMWGEWVDGN
NVISRTWVRA SAVAERLWSA KDVTSITSAI PRLDDQRCRM LKRGIRVGPV QGPGSCECDI
CV
//
