ID T1K8Y3_TETUR Unreviewed; 456 AA.
AC T1K8Y3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
GN Name=107361716 {ECO:0000313|EnsemblMetazoa:tetur07g03010.1};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur07g03010.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur07g03010.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC {ECO:0000256|RuleBase:RU365065}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU365065}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}.
CC -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC ECO:0000256|RuleBase:RU365065}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU365065}.
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DR EMBL; CAEY01001886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015784071.1; XM_015928585.1.
DR AlphaFoldDB; T1K8Y3; -.
DR EnsemblMetazoa; tetur07g03010.1; tetur07g03010.1; tetur07g03010.
DR GeneID; 107361716; -.
DR KEGG; tut:107361716; -.
DR eggNOG; KOG2601; Eukaryota.
DR HOGENOM; CLU_020370_1_0_1; -.
DR OMA; ASCVIFY; -.
DR OrthoDB; 38357at2759; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR009716; Ferroportin-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR PANTHER; PTHR11660:SF57; SOLUTE CARRIER FAMILY 40 PROTEIN; 1.
DR Pfam; PF06963; FPN1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|RuleBase:RU365065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365065};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365065};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT TRANSMEM 37..61
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 73..94
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 106..133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 274..295
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 404..425
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
SQ SEQUENCE 456 AA; 50302 MW; B2B5E5F297D3188F CRC64;
MDYRYKLYLN RLLSSWGDRT WEFAIGLYLI KLYPSSLLLT AIQGILASSA TIILAPIFGR
WITKASRIQE VKICLIIQNG AVVISSAFVA LFFLQDQIED ESIRNAIAFV APIVLVGFSL
ISQVTSAGYT LCLEKDWLVT LAEDEKRLTD LNAMLRRIDL SCQTVAPFLV GFLMQFSELA
SAVFFLVWNA FSGFGEYAVL KSLYNQGIPA LLEPKKDKPD LSNELSFFDF DALKKYWKSF
SLPGVAFGLV YLSILGFDSV TVGFMTSQGV EEGLIGIVSL FGAIFGILGT LVFQWSAARI
GLRLTGLIGY TIDLLALSLC LVIAISPNWF GWNWGSMTAP IILFLIGIAV SRAGLWTIDL
SVNQLIQTQS TKPALIGGVQ TSVNIFAELT KFTVVAFIPA LENFWILIIV SYLSITLGGI
LFALYTYRCR DITPPEATAL TEKSKIAYGT LTETKS
//
