ID T1K937_TETUR Unreviewed; 322 AA.
AC T1K937;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=tRNA (guanine(9)-N(1))-methyltransferase {ECO:0000256|ARBA:ARBA00012797};
DE EC=2.1.1.221 {ECO:0000256|ARBA:ARBA00012797};
GN Name=107361851 {ECO:0000313|EnsemblMetazoa:tetur07g03560.1};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur07g03560.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur07g03560.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:43156, Rhea:RHEA-COMP:10367, Rhea:RHEA-COMP:10368,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.221;
CC Evidence={ECO:0000256|ARBA:ARBA00000855};
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DR EMBL; CAEY01001888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015784266.1; XM_015928780.1.
DR AlphaFoldDB; T1K937; -.
DR STRING; 32264.T1K937; -.
DR EnsemblMetazoa; tetur07g03560.1; tetur07g03560.1; tetur07g03560.
DR GeneID; 107361851; -.
DR KEGG; tut:107361851; -.
DR eggNOG; KOG2967; Eukaryota.
DR HOGENOM; CLU_034384_7_0_1; -.
DR OMA; FKKNDGW; -.
DR OrthoDB; 2908056at2759; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0052905; F:tRNA (guanosine(9)-N1)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd18101; Trm10euk_A; 1.
DR Gene3D; 3.40.1280.30; -; 1.
DR InterPro; IPR028564; MT_TRM10-typ.
DR InterPro; IPR038459; MT_TRM10-typ_sf.
DR InterPro; IPR007356; tRNA_m1G_MeTrfase_euk.
DR InterPro; IPR016009; tRNA_MeTrfase_TRMD/TRM10.
DR PANTHER; PTHR13563; TRNA (GUANINE-9-) METHYLTRANSFERASE; 1.
DR PANTHER; PTHR13563:SF13; TRNA METHYLTRANSFERASE 10 HOMOLOG A; 1.
DR Pfam; PF01746; tRNA_m1G_MT; 1.
DR PROSITE; PS51675; SAM_MT_TRM10; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 80..280
FT /note="SAM-dependent MTase TRM10-type"
FT /evidence="ECO:0000259|PROSITE:PS51675"
FT REGION 283..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 322 AA; 36576 MW; AD4A4167737FE8DB CRC64;
MGDTSDEEKA LGKVKVIADQ LGLSLDEIKE KKYSKKTLKR MLKNKVYNET KIEKRKIQKQ
KRKAKRKELK ETLGINLSEK KPRLTMSESP NKVNIAIDLS FNSMMNEKEL RKLMKQIQRC
YSLNRRSDAP CQLYLTSLKD EIAKGLMSKQ PGFDYWDIHR KEEHFLDAFK DFKEKGTLIF
LSSDSPNLLP DVAEIQKRGG DYAYIIGGLV DHNVHKGLTL GLAQKSGIQT ARLPIDQCME
LCVSKVLAVN HVFEIMLNAT NGIAWSQSFM NVIPARKVKQ SDALKSIRQP KKEHKENSEN
VVQKDQVENQ SSASSGSESS TT
//
