ID T1KBZ3_TETUR Unreviewed; 1305 AA.
AC T1KBZ3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Latrophilin Cirl {ECO:0000256|ARBA:ARBA00015543};
GN Name=107362565 {ECO:0000313|EnsemblMetazoa:tetur08g05800.1};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur08g05800.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur08g05800.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBUNIT: Forms a heterodimer, consisting of a large extracellular
CC region non-covalently linked to a seven-transmembrane moiety.
CC {ECO:0000256|ARBA:ARBA00011834}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7
CC subfamily. {ECO:0000256|ARBA:ARBA00010933}.
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DR EMBL; CAEY01001956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015785148.1; XM_015929662.1.
DR STRING; 32264.T1KBZ3; -.
DR EnsemblMetazoa; tetur08g05800.1; tetur08g05800.1; tetur08g05800.
DR GeneID; 107362565; -.
DR KEGG; tut:107362565; -.
DR eggNOG; KOG4193; Eukaryota.
DR eggNOG; KOG4729; Eukaryota.
DR HOGENOM; CLU_261185_0_0_1; -.
DR OMA; MNGERIF; -.
DR OrthoDB; 1114672at2759; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd22830; Gal_Rha_Lectin_dCirl; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF347; LATROPHILIN CIRL; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1305
FT /note="Latrophilin Cirl"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004581230"
FT TRANSMEM 647..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 811..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 851..872
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 928..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 956..977
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..123
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 225..302
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 645..979
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 137..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1305 AA; 143065 MW; 748E74B62E76B73B CRC64;
MVVTFYFTLI PLVLLVSGLS EGDSSSNQHR TGYACEGLSL TLSCDEPYHI NLIRANFGRF
SISTCNTQGN LEWSVNCASP GSFALIKQNC NHKNRCLLPA SSAFFGDPCP GTYKYLEVHY
ECVPKISRPG SSDVRSMVDD IWSGSSSQSS EQSSKPKIIS PPPIIKPNIA PRTSSPTVSP
SPSDIYINNN DTIYVPHPYP RSTTPRPDLW SLTPSFDGPI DSNGQSAQYA SESSAQHSLN
NNHCLAGLSR DLFWNYTEVG QKATQACPNG SKGRAVWTCV RQEGVPQWIP PKPDFSDCQS
LWMSNLTNRL NKGDAVVGIA AELESKTRSL VLYGGDVYRA TELINQLVLK MEAVVEQFPD
QRQRSQIIKE LLISMQDSCS NLLRKNHQDS WLELRPNIRI EAATALIYTL ERTSLLLADT
KSTASDYIRA HDYIYLAIHT RDAKDLLDYP GKLILPLPPN SDDSETSLDH ASYSQFNGNS
VELSTEAIFD LGLNNGFTRL FVVMFKRLDS ILEPEYYKPP SLDEGVFKIL NSDIIGTTLS
LVGSTVSRVP YNSLRTGSVW IKITFRHLLV QNVTNPKCVY WDPDKLDWST KGSYLLLSNL
THTFCEYDHL GYFGLIMDHI DSPIETPTVP SGDLYYGNPE TDGTIRILLI LGSTLNSIIL
LIALVTLVLV RNLQTKESAL IHKNVTINLL LDHLVLLLIL GTYFSPSYFN SNSFNLMTSI
SSSSGYLYNN TSTLRSLGLL VALYHYFLLV HFVWILFDLF ELHYRLTRKQ FVDQSLVLGP
SGSVAVVNAA STVTTTSVLA GNINPVKLRR YLYITSYSVP LVVILLISWS TSSQALPMFA
NLCSLEARSH LASFVIASSI ILTGLGLILL LVTYSRIGLQ ATATAAAASL AASPSVPVGS
FVYPPGLMTS ADKFATDLML NRKLKISLFL RFSLNLLAAI NCALGVVYLT YKVSTIGYLF
ALTNVSLGLF VFSYYCLTKE NIRARYSLIC SYAARYVVCL KGDSKTDYLN NHGNHHHHHN
HPNVIHNLPL NSGLNDGLSR GIVVGGYNKN PSIPNLTGNP AQLTEPIIGN STSMGALSSM
ARDYATSKHY LASDAATTES GSDYGCRRLT AAAAAAAAAA NNAPHLITHG PTPNHFYHLY
NPKQPCNPYS CHHMIEHVYE CIDDEPYVAK VILPAGSAVA SATLGNYRLH SMAAAQAAAH
HGHHLHHLHF QQTLPNHYLG YHNLESLHNS GSQFDVTRSA VNPGSSVNFS PDRAASLGIS
MGGGGTLQRC LVSTSLSAKK AEPPITTTMP VTTTSSTAEH NLTPL
//
