ID T1KDX6_TETUR Unreviewed; 841 AA.
AC T1KDX6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=CNNM transmembrane domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur09g04570.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur09g04570.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ACDP family.
CC {ECO:0000256|ARBA:ARBA00010484}.
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DR EMBL; CAEY01002033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1KDX6; -.
DR STRING; 32264.T1KDX6; -.
DR EnsemblMetazoa; tetur09g04570.1; tetur09g04570.1; tetur09g04570.
DR eggNOG; KOG2118; Eukaryota.
DR HOGENOM; CLU_011310_1_2_1; -.
DR OMA; QDFTVFA; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF59; UNEXTENDED PROTEIN; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 241..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 237..416
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 435..496
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 503..570
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 140..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 94240 MW; 8BD59AA23B0B0868 CRC64;
MSLIIKKFKV SSKSPVNSIA SESVLRFYSP DVSTNSIPLG PFITGIHVEN DRASVDSLGV
NIIYADTKTS IRLFGTNFTN DTLIALTRVA SPANTNCNDL SRFETMQATY LTSTMALITI
KEPKSTDTLY LCAKNVGPGQ AKLKPKSLQK KSQGSVDGEN TVTQSDSKFK IKGKALSLFT
KGQGNEEYQD ETEQPIQSNY TVVFRDDPSS QRSTVIKPGD WIHQGTEPYL TIQITGRLLP
LGLQITLICV LLCLTGLFAG LNLGLMSLDK NELKVIALKG DDDEKRYAKT IEPLRRRGNF
LLCTILLSNV AINSTLTVLL DQLTSGILAI AISTILIVII GDIVPQAICS RHGLAVGAKT
IWITYLFMAL TAPLSWPISK ILDYALGDEI GQVYDRERLM EFIRITRDYS QLEPAEVNII
SGALELKKKT VGLIMTCLED VFMLPLATRL DFDTVSRIEK SGYSRIPIYK DDRKNIVGLL
YVKDLAFVDP DDNMPLTTLI EYYRHPLIYT WEDTTLDIAL AAFKEGKSHL SFVRRLFDDD
DHTDPYYEVV GVVTLEDVIE EILQTEIVDE TDVYTDNRLK QRRFRPSERD NSVFSSLRHC
QDNTAISPQM ILATYQFLSS SCSPFANQFI TETILRRLLS QRIYFHHVYD PERDDPEPRI
QIYTRDKPAD YFVMILEGRV QVTAGKEQLT FYGGPFTSFG SDALKILPSS TTSTNEQLES
AFVYKPDFTV EIIQTTTYLK ITRKLYLSAI KASQMDRGSS NVSSKSFSFP PLSSSASLSF
IIDSTELSKG SNNNPNTIIT TDAQQPQNEL RNEQETSSND LKFNSSTEVH SFINPSFEME
S
//
