ID T1KF65_TETUR Unreviewed; 3369 AA.
AC T1KF65;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Laminin subunit alpha {ECO:0008006|Google:ProtNLM};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur10g02030.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur10g02030.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; CAEY01000034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 32264.T1KF65; -.
DR EnsemblMetazoa; tetur10g02030.1; tetur10g02030.1; tetur10g02030.
DR eggNOG; KOG1836; Eukaryota.
DR HOGENOM; CLU_000301_1_0_1; -.
DR OMA; GECKCLT; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00055; EGF_Lam; 20.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 20.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR10574:SF444; -; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 21.
DR Pfam; PF02210; Laminin_G_2; 4.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00180; EGF_Lam; 22.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 4.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 18.
DR PROSITE; PS01248; EGF_LAM_1; 7.
DR PROSITE; PS50027; EGF_LAM_2; 14.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 1..159
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 320..365
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 366..411
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 412..457
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 458..507
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 547..601
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 602..654
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1226..1271
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1272..1317
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1318..1365
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1366..1416
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1439..1637
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1671..1720
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1758..1810
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1811..1857
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1858..1904
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2524..2729
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2755..2922
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2987..3171
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3177..3366
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 320..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 322..339
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 341..350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 366..378
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 368..385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 387..396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 412..424
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 414..431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 433..442
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 458..470
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 478..487
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 572..581
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 625..634
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1226..1238
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1228..1245
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1247..1256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1290..1299
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1341..1350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1366..1378
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1368..1385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1387..1396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1690..1699
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1782..1791
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1794..1808
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1830..1839
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1878..1887
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2895..2922
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 3369 AA; 374019 MW; 5D5FA4AAF88878E1 CRC64;
MNFNVSTYVL ASEYHVAYVY VTMANSPRPG VWVIERSVDG GSSFKPWMYF ADSKEECVRQ
FGEESIQPLT RDDQVICETK YSKLIPLEDG EIIILLLKNR PGGDNFTSSE ALQEFTRATN
IRLRFIRPLT FGINNLLNFE KTFLSRYFYS IREIKVGARC VCNGHAEACD FIDPNSPDKS
HCACRHNTTG VQCEKCKPPF MQKRWRPATP NDPFECEKCN CNGHSEECIF DDEGGGRCIK
CDHNTKGINC HECKFGFYRR KGLPLNATNI CVKCSCFKSS QTGGCDAETG LCQCKNNFTN
APACDKCAYG YYKEPDCPRC PCYRNGTLDD ICAPSRGQCI CKKSYSGADC SSCAASYWGF
PKCQPCNCDL SGSVSPNCDS TNGKCTCKKQ FSGNLCSSCS VGFFGFPECQ ACDCNPLGTF
EDVCNLTNGT CKCKPGFGGS RCDQCIPGYY GFPDCKPCTC YSEGSINENC SKDGKCSCHP
RYGGLKCNQC APGYFDFPKC EACGCDPAGS SGTSCLNGAC WCKDNFEGTK CNKCKKNYYN
YPTCESCSCN PAGIVSNFSR CSEIPSQKFC NCKERVVGRN CDTCAPHFKN LRAINPLGCD
PCRCNRAGSI NGLDYCDGDS GQCICKESVT GLTCDRCSYG TYALSSGNYL GCVPCDCDVG
GSWRSVCDKI TGACQCKFRI EGRRCDRPQI AHYFYTTYQY LYELEDGRGE YHSIRYDYNE
TVFPGFSWKG YAKFSEIQKK VTIDFFIIRS SFYRVIFHYH NPGTEPIVGN LTLTNENEPP
QYLKVTFAPT LKPKKYLVPM DKATPFHLFV TRRPWSASLT ADEPLLVDYI VFLPQAYFEA
TILRENVTGA CTVSTPTYQL CRHYGYTKFP PSSISYPKGF ANANVDIPAD ARDSFLINAV
SLSDQEREHV FDLDVDKESK YVLILSYVYR VTNPPPKGQI ARLTVEVNTL NKIKMNIPFQ
VPICQNTFPC RHVIVDNKGA PVKFHLANGP STVIVKLDNE IGEATFSILG LIFLPIRDWH
IDHVKPSLIC IMRNLECLDL PFDEMSESMK IPFNGQSTSS VSSNIIDESM GMIQLSGVAP
VTQNYILVVH YYQPDYPEFG IEITFLKSMQ SATEQATLKI SHCPNKNGCR SMIQFKKPLG
VLEAGKEFML IMNLPKDRFA NFENLLLISE KNFSPTQLKL PIVDRSTEFF AQCAQDAFYV
DDSSSEFCKQ AVFTLTTDHN SGGAFCGCNA TGSYGYTCKP LGGQCNCKPN IIGRECKACR
SGYYGFPDCK PCNCPKTVDY CDSVTGECVC PKNVVGNNCD RCAPLAYGYD SKMGCDECNC
HPLGVLDGNL KCDSRTGQCR CKAKYDGRIC SLCKIGYFDF PDCRRCNCHY DGTTSDVCDS
KSGSCYCKEN VLRPNCDVCK QGTFNLDPKN PEGCTKCFCF GVAKNCRSSE LKLTPVKAIN
YSNWSAVEIE FSESELSFTP IVTTSKLTET QFRLEPVPMG QVYLLSKSDS RKNFYFKVPN
EFLGNRLTSY GGFIRYQTVE LPLKGSVINS IDTPVTPDLI FIGRNHSIEL TNDEQPASPF
STQKFEIELV ESKFRHLYES TPVTREQFMT LLTDLQSIYI RASYFTPVGA VYLADFTFDL
ASNGSILNAS LARRVEQCSC PVNYKGSSCE ECASGYYRIS VGPYLGSCIP CKCHGHSNEC
DPLTGKCLNC NHNTTGDHCE LCKSGFYGNA TVGKPDDCLS CPCPSCNCKP GYTGKLCNLC
AVGYFGNPLI PGNFCQPCNC NGNIDSTDPD SCHSFSGNCA KCLNNTAGKS CERCADGYYG
DAIKLKNCRP CQCVNCGTAV CDQYSGNCKC HPNVIGDYCN ECKPNHYGFN TCAGCTPCNC
SDASKGHDCD ADSGQCRCQP GATGRTCNVC EPGFWKYSKL GCESCGCSEK YSKGVVCNQK
TGKCECLPGV VGEKCDKCPR RWVFVDQKGC HQCTDCQDTL LDDTDLLMNE ITPIFNDLSN
TAKSVYTAKK FSLLISNLTK LENKMSININ ASKLINLSTL GNEMVKIIKG SDNLSVWQER
LSHLASSVVK WNKTLSKADT ILHESKKVSN EVNKTIEQFK ATEHLYKTEA AEVSFPAMLS
QCESNTNEVK RVNSFIDGKT REVDDILNEL AFNFWSKVKR LFKDISALKT DANGFKERLN
RAVNILTDAN LKIANSTSVS LDVQRSLNIS HTSLKEPMIS NINLMKNLDS SIATHLKEAK
AKINQSSAIL IATSSSLVTL VELSYPVTTK KERLVGLLGK LKKLQELRLT NEVKKAIQYS
NNLNKTAINL GLTFSRVFEE ESLARKIKAA KAFGIVEKAI ESAENLVRDL NISSDKPWKK
IKDEISSVQQ DVMKNKGKAS ELKANILTIG AKDLYQKNET INLKDAMIKL QSQKLDKLII
ELGNTTENII AFNKDSKLME SIQLSAHIAN NVSTRFDQLV IDIDSISNAT NELKQDQEQI
FIDINEGTSL YTLYDPRKIR ERVHNSEVKV AEMMNLVKSS KPVIEKLKRM VIRARKMASH
IDLAMKLDKI SFAQLRLPEN LLRTSKSLTS LSLNFASIYN DGLLFFMGNL NKSQPQHVKR
STDKDLTNRN DYIAVCLNKG KVKVVLDLGS GPQSIETDDT FNDGDWTGLV FNRVGKKMNL
TMLKGDKMTV TVGYIEGSSF LFDLNNQSQI FVGLIPSDYI VPDTINANIF NGSLAHITYS
DIPISLHNFK RGFYSGGAFS PDPPKFKGCF KDELDNSKRT PGVTLGCVES RVTEAVFKTN
VRPSFIEMPL KKEIESFQIS FKFKTNLSKT IIFAMHMTPG ENTNMAFSSI FIEKGILKFV
TFPGGSAYSD VRCNDSEWHY VMLTKKGNSY KLNIDDKPEV SKDFPEQNLH ESAESYSIGG
SDEHIRGNFP VFIGCVGEIV VNNELQDLRN ADDVNAATLV NCDQQLINSD NDTSTEIIPN
LPSLTNTNIT PTTPAINPSL LANYTTVPNC ALPMVPIEPG VTIDSHGRRF GTSRHSRVEI
KLSSELIKSF ETGSNISLRF SPTRKMFGEG NRAGILFFVS DAQFDEFMCL YIYDQVMYLA
WNVGSGHKIL KGDWIISKSN VRITFGLNGN AGWVDSYTAT SPGNSTKFNI VSPAYIGGLP
PIAAHRVGPL IWNMNHSYIG CIRDIVINGI PISLEEKETE NGYKFVNTPI CTNQIESGVY
LTGQNSYLSC YDKFKVGLTV VIEFHIKPRI LNGLILATFG HPNEKGEISD YLIAKLNNGA
IQLTVNNGFG EKTATLDMKN GSAAICDGNW HMITITKISN SHMITVNKEE SEAVFGPGGF
NVADTSTPIF VGDVPDYYRR ILPDLPPPYI GCVSHMSAYS PKQRGYINYI SMGRYCDYIG
NAMEYCPIF
//
